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PMID: 10591208 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The DNA sequence of human chromosome 22.

Nature ·Vol. 402 ·No. 6761 ·1999-12-02 ·Pages 489-95

Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP

Abstract

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.

MeSH Terms

Animals Chromosome Mapping/methods Chromosomes, Human, Pair 22 DNA Gene Dosage Human Genome Project Humans Mice Molecular Sequence Data Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA Species Specificity

Chemicals

DNA

Authors & Affiliations

25 authors, click to expand affiliations / ORCID

Dunham I

Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. id1@sanger.ac.uk

Shimizu N

Roe B A

Chissoe S

Hunt A R

Collins J E

Bruskiewich R

Beare D M

Clamp M

Smink L J

Ainscough R

Almeida J P

Babbage A

Bagguley C

Bailey J

Barlow K

Bates K N

Beasley O

Bird C P

Blakey S

Bridgeman A M

Buck D

Burgess J

Burrill W D

O'Brien K P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/990031

id1@sanger.ac.uk

Published

1999-12-02

Pages

489-95

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

AC006285, AL023733, AL049708, AL049749, AL049760, AL050347, AL078611, AL096754, AP000522, AP000523, AP000524, AP000525, AP000526, AP000527, AP000528, AP000529, AP000530, AP000531, AP000532, AP000533, AP000534, AP000535, AP000536, AP000537, AP000538, AP000539, AP000540, AP000541, AP000542, Z75892

Corrections

ErratumIn

CommentIn

PMID: 10591190

CommentIn

PMID: 10591191

CommentIn

PMID: 10591200

CommentIn

PMID: 10638729

External Links

PubMed source DOI: 10.1038/990031 View journal details

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The DNA sequence of human chromosome 22.

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