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PMID: 12374839 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Conserved filamentous prophage in Escherichia coli O18:K1:H7 and Yersinia pestis biovar orientalis.

Journal of bacteriology ·Vol. 184 ·No. 21 ·2002-11-00 ·Pages 6050-5

Gonzalez MD, Lichtensteiger CA, Caughlan R, Vimr ER

Abstract

Microbial virulence is known to emerge by horizontal gene transfer mechanisms. Here we describe the discovery of a novel filamentous prophage, designated CUS-1, which is integrated into the chromosomal dif homologue of the high-virulence clone Escherichia coli O18:K1:H7. An homologous chromosomal element (CUS-2) in Yersinia pestis biovar orientalis is integrated at the same relative location as CUS-1; both lysogenic E. coli and Y. pestis strains produce particles with properties expected of single-stranded DNA virions. CUS(phi) is epidemiologically correlated with the emergence of K1 strains with increased virulence and with the Y. pestis biovar responsible for the current (third) plague pandemic.

MeSH Terms
Animals Bacteriophages/genetics,physiology Escherichia coli/genetics,virology Open Reading Frames Proviruses/genetics,physiology Rats Yersinia pestis/genetics,virology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gonzalez Mark D
Laboratory of Sialobiology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.
Lichtensteiger Carol A
Caughlan Ruth
Vimr Eric R
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.184.21.6050-6055.2002
Published
2002-11-00
Pages
6050-5
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC135385
Subset
IM
Grants
NIAID NIH HHS · R01 AI042015 · United States
NIAID NIH HHS · R56 AI042015 · United States
NIAID NIH HHS · AI42015 · United States
External Links
PubMed source DOI: 10.1128/JB.184.21.6050-6055.2002 PMC Full Text View journal details
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