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PMID: 1237149 Published · ppublish English Journal Article

DNA-synthesis in synchronized L-cells after irradiation during the G1-phase of the cell cycle.

Radiation and environmental biophysics ·Vol. 12 ·No. 1 ·1975-06-13 ·Pages 23-30

König K, Linden WA, Canstein M, Baisch H, Canstein L

Abstract

Mouse fibroblast L-929 cells synchonized by mitotic selection were irradiated during the G1-phase of the cell cycle with a dose of 1000 rad. The rat of DNA synthesis was measured by 3H-thymidine incorporation, and the progression of the cells through the cell cycle was determined using a pulse-cytophotometer. Irradiation caused a decrease in the rate of DNA synthesis to half the control value, and an extension of the S-phase to twice its normal duration.

MeSH Terms
Animals Cell Division/radiation effects DNA/biosynthesis L Cells/cytology,metabolism,radiation effects Mice Radiation Effects X-Rays
Chemicals
DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
König K
Linden W A
Canstein M
Baisch H
Canstein L
References (20)
20 references, click to expand
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Article Info
Journal
Radiation and environmental biophysics
Abbr.
Radiat Environ Biophys
ISSN
0301-634X
DOI
10.1007/BF02339806
Published
1975-06-13
Pages
23-30
Language
English
Region
Germany
NLM ID
0415677
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02339806 View journal details
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