Home LiteratureArticle Details
PMID: 12122039 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 22 ·No. 14 ·2002-07-15 ·Pages 5797-802

Haas CA, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, Zentner J, Frotscher M

Abstract

The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain. Reelin, which is synthesized and secreted by Cajal-Retzius cells in the marginal zone of the neocortex and hippocampus, is proposed to act as a stop signal for migrating neurons. Here we show that a decreased expression of reelin mRNA by hippocampal Cajal-Retzius cells correlates with the extent of migration defects in the dentate gyrus of patients with temporal lobe epilepsy. These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy.

MeSH Terms
Adaptor Proteins, Signal Transducing Adolescent Adult Cell Adhesion Molecules, Neuronal/genetics,metabolism Cell Count Cell Movement Child, Preschool Dentate Gyrus/pathology Epilepsy, Temporal Lobe/metabolism,pathology Extracellular Matrix Proteins/genetics,metabolism Female Hippocampus/metabolism,pathology Humans In Situ Hybridization LDL-Receptor Related Proteins Male Middle Aged Nerve Tissue Proteins/biosynthesis Neurons/metabolism,pathology Polymerase Chain Reaction RNA, Messenger/metabolism Receptors, LDL/biosynthesis Receptors, Lipoprotein/biosynthesis Reelin Protein Serine Endopeptidases
Chemicals
Adaptor Proteins, Signal Transducing Cell Adhesion Molecules, Neuronal DAB1 protein, human Extracellular Matrix Proteins LDL-Receptor Related Proteins Nerve Tissue Proteins RNA, Messenger Receptors, LDL Receptors, Lipoprotein Reelin Protein VLDL receptor low density lipoprotein receptor-related protein 8 RELN protein, human Serine Endopeptidases
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Haas Carola A
Institute of Anatomy, Department of Neurosurgery, University of Freiburg, D-79001 Freiburg, Germany. Carola.Haas@anat.uni-freiburg.de
Dudeck Oliver
Kirsch Matthias
Huszka Csaba
Kann Gunda
Pollak Stefan
Zentner Josef
Frotscher Michael
References (26)
26 references, click to expand
  1. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
    Cell. 1999 Jun 11;97(6):689-701 PMID: 10380922
  2. Reelin is a ligand for lipoprotein receptors.
    Neuron. 1999 Oct;24(2):471-9 PMID: 10571240
  3. Changes in the distribution and connectivity of interneurons in the epileptic human dentate gyrus.
    Neuroscience. 2000;96(1):7-25 PMID: 10683405
  4. Entorhinal cortex lesion does not alter reelin messenger RNA expression in the dentate gyrus of young and adult rats.
    Neuroscience. 2000;97(1):25-31 PMID: 10877665
  5. Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy.
    Hippocampus. 2000;10(3):305-24 PMID: 10902900
  6. Neuronal migration disorders: from genetic diseases to developmental mechanisms.
    Trends Neurosci. 2000 Aug;23(8):352-9 PMID: 10906798
  7. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations.
    Nat Genet. 2000 Sep;26(1):93-6 PMID: 10973257
  8. Glutamate release and neuronal damage in ischemia.
    Life Sci. 2001 Jun 15;69(4):369-81 PMID: 11459428
  9. Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis.
    J Neurosci. 2001 Sep 15;21(18):7171-81 PMID: 11549728
  10. Stereological estimates of total neuron numbers in the hippocampus of adult reeler mutant mice: Evidence for an increased survival of Cajal-Retzius cells.
    J Comp Neurol. 2001 Oct 8;439(1):19-31 PMID: 11579379
  11. Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy.
    Brain Res. 1990 Dec 10;535(2):195-204 PMID: 1705855
  12. Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients.
    Ann Neurol. 1991 Dec;30(6):741-9 PMID: 1789691
  13. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.
    J Comp Neurol. 1965 Jun;124(3):319-35 PMID: 5861717
  14. Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes.
    Brain. 1966 Sep;89(3):499-530 PMID: 5922048
  15. Cortical development: view from neurological mutants two decades later.
    Neuron. 1995 Jun;14(6):1101-4 PMID: 7605626
  16. The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons.
    Nat Genet. 1995 May;10(1):77-83 PMID: 7647795
  17. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
    Nature. 1995 Apr 20;374(6524):719-23 PMID: 7715726
  18. The neuropathology of temporal lobe epilepsy.
    J Neuropathol Exp Neurol. 1993 Sep;52(5):433-43 PMID: 8360697
  19. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections.
    Nature. 1997 Jan 2;385(6611):70-4 PMID: 8985248
  20. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.
    J Neurosci. 1997 Jan 1;17(1):23-31 PMID: 8987733
  21. Developmental spectrum of the excitotoxic cascade induced by ibotenate: a model of hypoxic insults in fetuses and neonates.
    Neuropathol Appl Neurobiol. 1996 Dec;22(6):498-502 PMID: 9004236
  22. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus.
    J Neurosci. 1997 May 15;17(10):3727-38 PMID: 9133393
  23. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.
    Nature. 1997 Oct 16;389(6652):730-3 PMID: 9338784
  24. Neuronal position in the developing brain is regulated by mouse disabled-1.
    Nature. 1997 Oct 16;389(6652):733-7 PMID: 9338785
  25. Prenatal development of reelin-immunoreactive neurons in the human neocortex.
    J Comp Neurol. 1998 Jul 20;397(1):29-40 PMID: 9671277
  26. An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy.
    Acta Neuropathol. 1999 Jan;97(1):31-9 PMID: 9930892
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
20026621
Email
carola.haas@anat.uni-freiburg.de
Published
2002-07-15
Pages
5797-802
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6757930
Subset
IM
External Links
PubMed source DOI: 20026621 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2