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PMID: 12110130 Published · ppublish English Journal Article Review

The immunological synapse.

Arthritis research ·Vol. 4 Suppl 3 ·2002-00-00 ·Pages S119-25

Dustin ML

Abstract

T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell-cell junction referred to as an immunological synapse. The immunological synapse contains at least two functional domains: a central cluster of engaged antigen receptors and a surrounding ring of adhesion molecules. The segregation of the T-cell antigen receptor (TCR) and adhesion molecules is based on size, with the TCR interaction spanning 15 nm and the lymphocyte-function-associated antigen-1 (LFA-1) interaction spanning 30-40 nm between the two cells. Therefore, the synapse is not an empty gap, but a space populated by both adhesion and signaling molecules. This chapter considers four aspects of the immunological synapse: the role of migration and stop signals, the role of the cytoskeleton, the role of self-antigenic complexes, and the role of second signals.

MeSH Terms
Animals Antigen-Presenting Cells/cytology,immunology Humans Intercellular Junctions/immunology Signal Transduction/immunology T-Lymphocytes/cytology,immunology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dustin Michael L
Department of Pathology, New York University School of Medicine, Skirball Institute for Biomolecular Medicine, New York 10016, USA. dustin@saturn.med.nyu.edu
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Article Info
Journal
Arthritis research
Abbr.
Arthritis Res
ISSN
1465-9905
DOI
10.1186/ar559
Email
dustin@saturn.med.nyu.edu
Published
2002-00-00
Epub
2002-00-09
Pages
S119-25
Language
English
Region
England
NLM ID
100913255
PMCID
PMC3240135
Subset
IM
External Links
PubMed source DOI: 10.1186/ar559 PMC Full Text
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