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PMID: 11283156 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.

The Journal of experimental medicine ·Vol. 193 ·No. 7 ·2001-04-02 ·Pages 839-46

Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H

Abstract

Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell stimulatory capacity, direct the activation and differentiation of T cells by providing costimulatory signals. As such, they are critical regulators of both natural and vaccine-induced immune responses. A new B7 family member, B7-DC, whose expression is highly restricted to DCs, was identified among a library of genes differentially expressed between DCs and activated macrophages. B7-DC fails to bind the B7.1/2 receptors CD28 and cytotoxic T lymphocyte-associated antigen (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. B7-DC costimulates T cell proliferation more efficiently than B7.1 and induces a distinct pattern of lymphokine secretion. In particular, B7-DC strongly costimulates interferon gamma but not interleukin (IL)-4 or IL-10 production from isolated naive T cells. These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses.

MeSH Terms
Amino Acid Sequence Animals Antigen Presentation Antigens, CD Antigens, Surface Apoptosis Regulatory Proteins B7-1 Antigen/immunology CD28 Antigens/metabolism Dendritic Cells/immunology Gene Library Humans Interferon-gamma/metabolism Mice Mice, Inbred BALB C Molecular Sequence Data Programmed Cell Death 1 Ligand 2 Protein Programmed Cell Death 1 Receptor Protein Binding Proteins/metabolism Sequence Homology, Amino Acid T-Lymphocytes/immunology
Chemicals
Antigens, CD Antigens, Surface Apoptosis Regulatory Proteins B7-1 Antigen CD28 Antigens PDCD1 protein, human PDCD1LG2 protein, human Pdcd1 protein, mouse Pdcd1lg2 protein, mouse Programmed Cell Death 1 Ligand 2 Protein Programmed Cell Death 1 Receptor Proteins Interferon-gamma
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Tseng S Y
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Otsuji M
Gorski K
Huang X
Slansky J E
Pai S I
Shalabi A
Shin T
Pardoll D M
Tsuchiya H
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.193.7.839
Published
2001-04-02
Pages
839-46
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2193370
Subset
IM
Databases
GENBANK
AF142780, AF329193
External Links
PubMed source DOI: 10.1084/jem.193.7.839 PMC Full Text View journal details
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