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PMID: 7546405 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice.

Current opinion in immunology ·Vol. 7 ·No. 3 ·1995-06-00 ·Pages 389-95

Sharpe AH

Abstract

The use of transgenic technologies in the functional evaluation of the contributions of costimulatory pathways to T-cell activation in vivo has recently undergone a rapid expansion. During the past two years, mice deficient in costimulatory molecules and their receptors have been generated. These mice have revealed novel and critical in vivo functions of costimulatory pathways and have provided valuable models in which to test therapeutic strategies involving costimulatory pathway blockade. Transgenic mice constitutively expressing costimulatory molecules have provided insights into their role in peripheral tolerance.

MeSH Terms

Abatacept Animals Antigens, CD Antigens, Differentiation/immunology B7-1 Antigen/immunology CD11 Antigens/immunology CD18 Antigens/immunology CD2 Antigens/immunology CD28 Antigens/immunology CD40 Antigens/immunology CD58 Antigens/immunology CTLA-4 Antigen Cell Adhesion Molecules/immunology Cell Communication Immunoconjugates Integrin alpha4beta1 Integrin beta1/immunology Integrins/immunology Intercellular Adhesion Molecule-1/immunology Lymphocyte Activation Lymphocyte Function-Associated Antigen-1/immunology Mice Mice, Knockout/immunology Mice, Transgenic/immunology Receptors, Immunologic/antagonists & inhibitors Receptors, Lymphocyte Homing/immunology Receptors, Very Late Antigen/immunology Signal Transduction Vascular Cell Adhesion Molecule-1/immunology

Chemicals

Antigens, CD Antigens, Differentiation B7-1 Antigen CD11 Antigens CD18 Antigens CD2 Antigens CD28 Antigens CD40 Antigens CD58 Antigens CTLA-4 Antigen Cell Adhesion Molecules Ctla4 protein, mouse Immunoconjugates Integrin alpha4beta1 Integrin beta1 Integrins Lymphocyte Function-Associated Antigen-1 Receptors, Immunologic Receptors, Lymphocyte Homing Receptors, Very Late Antigen Vascular Cell Adhesion Molecule-1 Intercellular Adhesion Molecule-1 Abatacept

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Sharpe A H

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(95)80115-4

Published

1995-06-00

Pages

389-95

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(95)80115-4 View journal details

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Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice.

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