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PMID: 12011027 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.

Infection and immunity ·Vol. 70 ·No. 6 ·2002-06-00 ·Pages 3287-9

Shubitz L, Peng T, Perrill R, Simons J, Orsborn K, Galgiani JN

Abstract

Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.

MeSH Terms
Administration, Intranasal Animals Antigens, Fungal/administration & dosage,immunology Coccidioides/immunology Coccidioidomycosis/mortality,prevention & control Disease Models, Animal Female Fungal Proteins Fungal Vaccines/administration & dosage,immunology Glycoproteins/administration & dosage,immunology Injections, Subcutaneous Lung/microbiology,pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Spleen/microbiology,pathology Vaccination Vaccines, Synthetic/administration & dosage,immunology Weight Loss
Chemicals
Antigens, Fungal Fungal Proteins Fungal Vaccines Glycoproteins Vaccines, Synthetic antigen 2, Coccidioides
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Shubitz Lisa
Valley Fever Center for Excellence, Medicine and Subspecialties Program, Research Program, Southern Arizona Veterans Affairs Health Care System, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona 85723, USA.
Peng Tao
Perrill Robert
Simons Julie
Orsborn Kris
Galgiani John N
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.70.6.3287-3289.2002
Published
2002-06-00
Pages
3287-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC127985
Subset
IM
Grants
PHS HHS · 5 P01 A/37232-06 · United States
External Links
PubMed source DOI: 10.1128/IAI.70.6.3287-3289.2002 PMC Full Text View journal details
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