Home LiteratureArticle Details
PMID: 9573127 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.

Infection and immunity ·Vol. 66 ·No. 5 ·1998-05-00 ·Pages 2342-5

Zimmermann CR, Johnson SM, Martens GW, White AG, Zimmer BL, Pappagianis D

Abstract

The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.

MeSH Terms
Animals Coccidioides/immunology Coccidioidomycosis/prevention & control Fungal Vaccines/immunology Immunization Mice Rabbits
Chemicals
Fungal Vaccines
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zimmermann C R
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616, USA. crzimmermann@ucdavis.edu
Johnson S M
Martens G W
White A G
Zimmer B L
Pappagianis D
References (25)
25 references, click to expand
  1. Coccidioides immitis vaccine: potential of an alkali-soluble, water-soluble cell wall antigen.
    Infect Immun. 1983 Jan;39(1):473-5 PMID: 6822433
  2. Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis.
    Infect Immun. 1988 Jan;56(1):13-7 PMID: 3335400
  3. Immunity to coccidioi-domycosis induced in mice by purified spherule, arthrospore, and mycelial vaccines.
    Trans N Y Acad Sci. 1960 Apr;22:436-49 PMID: 14416255
  4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  5. Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.
    J Infect Dis. 1996 Aug;174(2):440-3 PMID: 8699085
  6. Inbred mouse strains differ in resistance to lethal Coccidioides immitis infection.
    Infect Immun. 1983 Jun;40(3):912-6 PMID: 6852925
  7. Immunization of mice against coccidioidomycosis with a subcellular vaccine.
    Infect Immun. 1979 Jul;25(1):440-5 PMID: 478645
  8. Serology of coccidioidomycosis.
    Clin Microbiol Rev. 1990 Jul;3(3):247-68 PMID: 2200605
  9. Activation of macrophages by lymphokines: enhancement of phagosome-lysosome fusion and killing of Coccidioides immitis.
    Infect Immun. 1983 Mar;39(3):1201-7 PMID: 6601622
  10. Natural killer cell inhibition of young spherules and endospores of Coccidioides immitis.
    J Immunol. 1987 Nov 1;139(9):3107-11 PMID: 2444651
  11. Mechanisms of resistance to infection with Coccidioides immitis in mice.
    Infect Immun. 1979 Mar;23(3):681-5 PMID: 313369
  12. Vaccination of mice against Coccidoides immitis.
    Am Rev Tuberc. 1956 Aug;74(2 Part 1):245-8 PMID: 13340152
  13. Evaluation of the protective efficacy of the killed Coccidioides immitis spherule vaccine in humans. The Valley Fever Vaccine Study Group.
    Am Rev Respir Dis. 1993 Sep;148(3):656-60 PMID: 8368636
  14. Immunogenic properties of nondisrupted and disrupted spherules of Coccidioides immitis in mice.
    Sabouraudia. 1963 Feb;2:131-42 PMID: 14034579
  15. Identification of antigens of Coccidioides immitis which stimulated immune T lymphocytes.
    Arch Med Res. 1993 Autumn;24(3):281-91 PMID: 8298279
  16. Immunogenicity of spherule-endospore vaccines of Coccidioides immitis for mice.
    J Immunol. 1961 Aug;87:218-27 PMID: 13761478
  17. In vitro assessment of cellular immunity in human coccidioidomycosis: relationship between dermal hypersensitivity, lymphocyte transformation, and lymphokine production by peripheral blood mononuclear cells from healthy adults.
    J Infect Dis. 1992 Apr;165(4):710-5 PMID: 1552200
  18. Delayed-type hypersensitivity responses to a cell wall fraction of the mycelial phase of Coccidioides immitis.
    Infect Immun. 1975 Nov;12(5):1093-7 PMID: 1193725
  19. Significance of T cells in resistance to experimental murine coccidioidomycosis.
    Infect Immun. 1977 Sep;17(3):580-5 PMID: 332628
  20. Influence of vaccination on respiratory coccidiodial disease in cynomolgous monkeys.
    J Immunol. 1962 Aug;89:242-51 PMID: 14464610
  21. Identification of a Coccidioides immitis antigen 2 domain that expresses B-cell-reactive epitopes.
    Infect Immun. 1997 Aug;65(8):3376-80 PMID: 9234800
  22. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  23. Spectrum of in vivo and in vitro cell-mediated immune responses in coccidioidomycosis.
    Cell Immunol. 1977 Jun 1;31(1):130-41 PMID: 141334
  24. Effects of recombinant gamma interferon and tumor necrosis factor on in vitro interactions of human mononuclear phagocytes with Coccidioides immitis.
    Infect Immun. 1991 Nov;59(11):4227-9 PMID: 1937779
  25. IMMUNIZATION OF MICE TO COCCIDIOIDES IMMITIS: DOSE, REGIMEN AND SPHERULATION STAGE OF KILLED SPHERULE VACCINES.
    J Immunol. 1965 Jan;94:132-42 PMID: 14253511
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.66.5.2342-2345.1998
Email
crzimmermann@ucdavis.edu
Published
1998-05-00
Pages
2342-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC108201
Subset
IM
Grants
NIAID NIH HHS · N01 AI065296 · United States
NIAID NIH HHS · N01-AI-65296 · United States
External Links
PubMed source DOI: 10.1128/IAI.66.5.2342-2345.1998 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2