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PMID: 11914174 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Family, twin, and adoption studies of bipolar disease.

Current psychiatry reports ·Vol. 4 ·No. 2 ·2002-04-00 ·Pages 130-3

Taylor L, Faraone SV, Tsuang MT

Abstract

Bipolar disease features states of severe depression that usually fluctuate with at least one episode of intense elation or mania. It is a disorder that has been thought for some time to have a heritable component. The lifetime prevalence of bipolar disease in the general population is approximately 1%. In contrast, family studies have shown the approximate lifetime risk of a first-degree relative of a bipolar proband to be 5% to 10%. Moreover, studies of monozygotic twins show that their risk of contracting the disease is as much as 75 times greater than that for the general population. In addition, adoption studies have demonstrated that biological relatives of bipolar patients are substantially more likely to have the disorder than are adoptive relatives.

MeSH Terms
Adoption Bipolar Disorder/genetics,psychology Family/psychology Humans Psychotic Disorders/epidemiology,etiology Twins/psychology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taylor Levi
Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA.
Faraone Stephen V
Tsuang Ming T
References (35)
35 references, click to expand
  1. Familial rates of affective disorder. A report from the National Institute of Mental Health Collaborative Study.
    Arch Gen Psychiatry. 1987 May;44(5):461-9 PMID: 3579497
  2. Molecular genetics of bipolar disorder.
    Br J Psychiatry. 2001 Jun;178(Suppl 41):S128-33 PMID: 11388951
  3. A manic depressive history.
    Nat Genet. 1996 Apr;12(4):351-3 PMID: 8630482
  4. The treated incidence of psychotic and affective illness in twins compared with population expectation: a study in the Swedish Twin and Psychiatric Registries.
    Psychol Med. 1996 Nov;26(6):1135-44 PMID: 8931159
  5. The distinction of bipolar II disorder from bipolar I and recurrent unipolar depression: results of a controlled family study.
    Acta Psychiatr Scand. 1993 Apr;87(4):279-84 PMID: 8488750
  6. A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder.
    Psychiatry Res. 2001 Feb 28;106(1):25-34 PMID: 11231097
  7. Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships.
    Am J Psychiatry. 2000 Dec;157(12):2048-50 PMID: 11097977
  8. Similar effect of family history of psychosis on Sylvian fissure size and auditory P200 amplitude in schizophrenic and bipolar subjects.
    Psychiatry Res. 2001 Nov 5;108(1):29-38 PMID: 11677065
  9. Suicidality in bipolar compared to unipolar depressed inpatients.
    Eur Arch Psychiatry Clin Neurosci. 2000;250(5):257-61 PMID: 11097169
  10. Evaluating the parent-of-origin effect in bipolar affective disorder. Is a more penetrant subtype transmitted paternally?
    J Affect Disord. 2000 Sep;59(3):183-92 PMID: 10854635
  11. Prevalence and description of psychotic features in bipolar mania.
    Curr Psychiatry Rep. 2000 Aug;2(4):286-90 PMID: 11122970
  12. Parsing the association between bipolar, conduct, and substance use disorders: a familial risk analysis.
    Biol Psychiatry. 2000 Dec 1;48(11):1037-44 PMID: 11094136
  13. Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study.
    Biol Psychiatry. 2001 Mar 1;49(5):405-9 PMID: 11274651
  14. A family study of bipolar II disorder.
    Br J Psychiatry. 1984 Jul;145:49-54 PMID: 6743943
  15. Adoption study supporting genetic transmission in manic--depressive illness.
    Nature. 1977 Jul 28;268(5618):327-9 PMID: 887159
  16. Genetics of bipolar affective disorder.
    Curr Psychiatry Rep. 2000 Apr;2(2):147-57 PMID: 11122948
  17. A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands.
    Arch Gen Psychiatry. 1982 Oct;39(10):1157-67 PMID: 7125846
  18. The familial aggregation of psychotic symptoms in bipolar disorder pedigrees.
    Am J Psychiatry. 2001 Aug;158(8):1258-64 PMID: 11481160
  19. The familial transmission of bipolar illness.
    Arch Gen Psychiatry. 1987 May;44(5):441-7 PMID: 3579495
  20. The common genetic liability between schizophrenia and bipolar disorder: a review.
    Curr Psychiatry Rep. 2001 Aug;3(4):332-7 PMID: 11470041
  21. Psychiatric illness in relatives of probands with delusional depression.
    Psychopharmacol Bull. 1984 Summer;20(3):358-61 PMID: 6473630
  22. Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study.
    Arch Gen Psychiatry. 1993 Nov;50(11):871-83 PMID: 8215813
  23. Genetics of bipolar disorder.
    J Med Genet. 1999 Aug;36(8):585-94 PMID: 10465107
  24. Genetic factors in moderately severe and mild affective disorders.
    Arch Gen Psychiatry. 1986 Mar;43(3):222-6 PMID: 3954541
  25. Risks of affective illness among first-degree relatives of bipolar I old-order Amish probands.
    Arch Gen Psychiatry. 1992 Sep;49(9):703-8 PMID: 1514875
  26. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey.
    Arch Gen Psychiatry. 1994 Jan;51(1):8-19 PMID: 8279933
  27. Stability of psychotic symptomatology (delusions, hallucinations), affective syndromes, and schizophrenic symptoms (thought disorder, incongruent affect) over episodes in remitting psychoses.
    Eur Arch Psychiatry Neurol Sci. 1985;234(5):303-7 PMID: 3987739
  28. A Danish twin study of manic-depressive disorders.
    Br J Psychiatry. 1977 Apr;130:330-51 PMID: 558030
  29. The structure of psychosis: latent class analysis of probands from the Roscommon Family Study.
    Arch Gen Psychiatry. 1998 Jun;55(6):492-9 PMID: 9633666
  30. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series.
    Arch Gen Psychiatry. 1999 Feb;56(2):162-8 PMID: 10025441
  31. Are schizophrenic and bipolar disorders related? A review of family and molecular studies.
    Biol Psychiatry. 2000 Sep 15;48(6):531-8 PMID: 11018225
  32. A pilot Swedish twin study of affective illness, including hospital- and population-ascertained subsamples.
    Arch Gen Psychiatry. 1993 Sep;50(9):699-700 PMID: 8357295
  33. Are schizophrenia and affective disorder related? preliminary data from a family study.
    Am J Psychiatry. 1993 Feb;150(2):278-85 PMID: 8304989
  34. Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders.
    Arch Gen Psychiatry. 1986 Oct;43(10):923-9 PMID: 3753159
  35. Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions.
    Br J Psychiatry. 1980 Dec;137:497-504 PMID: 7214104
Article Info
Journal
Current psychiatry reports
Abbr.
Curr Psychiatry Rep
ISSN
1523-3812
DOI
10.1007/s11920-002-0046-1
Published
2002-04-00
Pages
130-3
Language
English
Region
United States
NLM ID
100888960
Subset
IM
Grants
NIMH NIH HHS · 1-R01MH41879-01 · United States
NIMH NIH HHS · 5-OU1MH46318-02 · United States
NIMH NIH HHS · R37MH43518-01 · United States
External Links
PubMed source DOI: 10.1007/s11920-002-0046-1 View journal details
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