Opening chromatin.

Molecular cell ·Vol. 9 ·No. 2 ·2002-02-00 ·Pages 209-11

Lomvardas S, Thanos D

Abstract

How the transcriptional apparatus gains access to and subsequently opens compacted chromatin has remained a mystery. Now in this issue of Molecular Cell, Zaret and coworkers show that chromatin opening in vitro is not mediated by the classical chromatin remodeling machines but instead occurs through specific transcription factor-histone interactions.

MeSH Terms

Animals Chromatin/genetics,metabolism,ultrastructure DNA-Binding Proteins/physiology Endoderm/metabolism Enhancer Elements, Genetic/physiology Fetal Proteins/biosynthesis,genetics GATA4 Transcription Factor Gene Expression Regulation, Developmental/physiology Gene Silencing Hepatocyte Nuclear Factor 3-alpha Histones/physiology Liver/embryology,metabolism Macromolecular Substances Mice Models, Genetic Nuclear Proteins/physiology Nucleosomes/physiology Promoter Regions, Genetic/physiology Serum Albumin/biosynthesis,genetics Transcription Factors/physiology Transcription, Genetic/physiology

Chemicals

Chromatin DNA-Binding Proteins Fetal Proteins Foxa1 protein, mouse GATA4 Transcription Factor Hepatocyte Nuclear Factor 3-alpha Histones Macromolecular Substances Nuclear Proteins Nucleosomes Serum Albumin Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lomvardas Stavros

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Thanos Dimitris

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/s1097-2765(02)00463-x

Published

2002-02-00

Pages

209-11

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 11864602

External Links

PubMed source DOI: 10.1016/s1097-2765(02)00463-x View journal details

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