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PMID: 1177140 Published · ppublish English Journal Article

Actions of gamma-aminobutyric acid on sympathetic ganglion cells.

The Journal of physiology ·Vol. 250 ·No. 1 ·1975-08-00 ·Pages 85-120

Adams PR, Brown DA

Abstract

1. Responses of single ganglion cells in the isolated rat superior cervical ganglion to gamma-aminobutyric acid (GABA) applied via the bathing medium were recorded using intracellular micro-electrodes. 2. GABA produced a large fall in cell input resistance, frequently to immeasurable levels. In thirteen cells showing a modest response to 100 muM GABA, input resistance fell from 50-5 +/-9-5 to 15.9 +/- 3-2 Momega (means +/- S.E. of mean). After correction for resistance leaks introduced by the impaling electrode, the resting membrane resistance Rm and the resistance of the GABA-shunt Rg in these cells were calculated to be 79-3 +/- 16-6 and 35-0 +/- 9-5 Momega respectively. 3. Cells with recorded resting membrane potentials greater than -42 mV were depolarized by GABA; at resting potential less than -42 mV they were hyperpolarized...

MeSH Terms
Aminobutyrates/pharmacology Animals Bromides/pharmacology Cell Membrane Permeability/drug effects Cervical Plexus Chlorides/pharmacology Choline/pharmacology Electrophysiology/drug effects Ganglia, Autonomic/drug effects Glutamates/pharmacology In Vitro Techniques Isethionic Acid/pharmacology Membrane Potentials/drug effects Neurons/drug effects Rats Sulfates/pharmacology gamma-Aminobutyric Acid/pharmacology
Chemicals
Aminobutyrates Bromides Chlorides Glutamates Sulfates gamma-Aminobutyric Acid Isethionic Acid Choline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Adams P R
Brown D A
References (38)
38 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1975.sp011044
Published
1975-08-00
Pages
85-120
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1348340
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1975.sp011044 PMC Full Text View journal details
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