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PMID: 11721624 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The biology of endotoxin.

Molecular biotechnology ·Vol. 19 ·No. 3 ·2001-11-00 ·Pages 279-96

Heine H, Rietschel ET, Ulmer AJ

Abstract

Endotoxin (lipopolysaccharide, LPS) is the major component of the outer leaflet of Gram-negative bacteria and has profound immunostimulatory and inflammatory capacity. The septic shock syndrome caused by endotoxin still has an unacceptably high mortality rate and, owing to increasing numbers of resistant strains, remains an ongoing threat throughout the world. However, the past years have provided new insights especially into the receptors of the innate immune system that are involved into the recognition of LPS and the initial signal transduction pathways that are engaged after the primary recognition on the cell surface. The knowledge about the molecular basis for the responses to endotoxin may eventually lead to the development of new drugs to fight the fatal effects of bacterial infections.

MeSH Terms
Animals Bone Marrow Cells/physiology Endotoxins/physiology Humans Lymphocytes/classification,physiology Mice
Chemicals
Endotoxins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Heine H
Research Center Borstel, Center for Medicine and Biosciences, Parkallee 22, D-23845 Borstel, Germany. hheine@fz-borstel.de
Rietschel E T
Ulmer A J
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Article Info
Journal
Molecular biotechnology
Abbr.
Mol Biotechnol
ISSN
1073-6085
DOI
10.1385/MB:19:3:279
Email
hheine@fz-borstel.de
Published
2001-11-00
Pages
279-96
Language
English
Region
United States
NLM ID
9423533
Subset
IM
External Links
PubMed source DOI: 10.1385/MB:19:3:279 View journal details
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