Home LiteratureArticle Details
PMID: 11713262 Published · ppublish English Journal Article Review

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis.

Molecular and cellular biology ·Vol. 21 ·No. 24 ·2001-12-00 ·Pages 8247-54

Krueger A, Baumann S, Krammer PH, Kirchhoff S

Abstract

暂无摘要

MeSH Terms
Animals Apoptosis Arabidopsis Proteins CASP8 and FADD-Like Apoptosis Regulating Protein Carrier Proteins/chemistry,physiology Caspases/metabolism Fatty Acid Desaturases/chemistry,metabolism Humans Intracellular Signaling Peptides and Proteins Models, Biological NF-kappa B/metabolism Protein Isoforms Protein Structure, Tertiary Receptors, Tumor Necrosis Factor/metabolism Transcription, Genetic fas Receptor/metabolism
Chemicals
Arabidopsis Proteins CASP8 and FADD-Like Apoptosis Regulating Protein CFLAR protein, human Carrier Proteins Intracellular Signaling Peptides and Proteins NF-kappa B Protein Isoforms Receptors, Tumor Necrosis Factor fas Receptor Fatty Acid Desaturases Fad7 protein, Arabidopsis Caspases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Krueger A
Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Baumann S
Krammer P H
Kirchhoff S
References (89)
89 references, click to expand
  1. TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia.
    Eur J Immunol. 2000 Dec;30(12):3680-8 PMID: 11169411
  2. FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis.
    J Exp Med. 2001 Feb 19;193(4):447-58 PMID: 11181697
  3. Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity.
    J Virol. 2000 Dec;74(24):11919-27 PMID: 11090192
  4. Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression.
    J Exp Med. 1998 Nov 16;188(10):1795-802 PMID: 9815257
  5. Inhibition of death receptor signals by cellular FLIP.
    Nature. 1997 Jul 10;388(6638):190-5 PMID: 9217161
  6. Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma.
    Blood. 1999 Sep 1;94(5):1727-37 PMID: 10477698
  7. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
    J Biol Chem. 1997 Jul 25;272(30):18542-5 PMID: 9228018
  8. Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
    Immunity. 2000 Jun;12(6):633-42 PMID: 10894163
  9. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
    Science. 1998 Mar 20;279(5358):1954-8 PMID: 9506948
  10. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex.
    J Biol Chem. 2001 Jun 8;276(23):20633-40 PMID: 11279218
  11. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.
    Curr Biol. 2000 Jun 1;10(11):640-8 PMID: 10837247
  12. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
    Science. 2000 Jun 30;288(5475):2354-7 PMID: 10875918
  13. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.
    J Biol Chem. 2001 Mar 9;276(10):6893-6 PMID: 11145953
  14. On the role of antigen in maintaining cytotoxic T-cell memory.
    Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9716-23 PMID: 8790397
  15. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
    Immunity. 1998 May;8(5):615-23 PMID: 9620682
  16. A role for FADD in T cell activation and development.
    Immunity. 1998 Apr;8(4):439-49 PMID: 9586634
  17. TRAIL receptor-2 signals apoptosis through FADD and caspase-8.
    Nat Cell Biol. 2000 Apr;2(4):241-3 PMID: 10783243
  18. Activation of the NF-kappaB pathway by caspase 8 and its homologs.
    Oncogene. 2000 Sep 14;19(39):4451-60 PMID: 11002417
  19. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis.
    J Immunol. 1999 May 1;162(9):5205-11 PMID: 10227994
  20. The role of c-FLIP in modulation of CD95-induced apoptosis.
    J Biol Chem. 1999 Jan 15;274(3):1541-8 PMID: 9880531
  21. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
    Nature. 1997 Apr 3;386(6624):517-21 PMID: 9087414
  22. Primed T cells are more resistant to Fas-mediated activation-induced cell death than naive T cells.
    J Immunol. 1999 Aug 1;163(3):1315-20 PMID: 10415029
  23. Two CD95 (APO-1/Fas) signaling pathways.
    EMBO J. 1998 Mar 16;17(6):1675-87 PMID: 9501089
  24. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
    EMBO J. 1997 May 15;16(10):2794-804 PMID: 9184224
  25. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
    Science. 2000 Jun 30;288(5475):2351-4 PMID: 10875917
  26. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.
    Cancer Res. 2000 Jul 15;60(14):3947-56 PMID: 10919673
  27. MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly.
    EMBO J. 2000 Oct 16;19(20):5418-28 PMID: 11032809
  28. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity.
    J Exp Med. 1998 Apr 20;187(8):1205-13 PMID: 9547332
  29. Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.
    Cell. 1996 Oct 18;87(2):319-29 PMID: 8861915
  30. NF-kappaB signals induce the expression of c-FLIP.
    Mol Cell Biol. 2001 Aug;21(16):5299-305 PMID: 11463813
  31. IAP family proteins--suppressors of apoptosis.
    Genes Dev. 1999 Feb 1;13(3):239-52 PMID: 9990849
  32. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD).
    J Biol Chem. 2000 Aug 11;275(32):24357-66 PMID: 10823821
  33. CASH, a novel caspase homologue with death effector domains.
    J Biol Chem. 1997 Aug 8;272(32):19641-4 PMID: 9289491
  34. Monoclonal antibody-mediated tumor regression by induction of apoptosis.
    Science. 1989 Jul 21;245(4915):301-5 PMID: 2787530
  35. Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis.
    Blood. 2000 Oct 1;96(7):2628-31 PMID: 11001921
  36. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis.
    J Biol Chem. 1997 Apr 11;272(15):9621-4 PMID: 9092488
  37. Differential sialylation of cell surface glycoconjugates in a human B lymphoma cell line regulates susceptibility for CD95 (APO-1/Fas)-mediated apoptosis and for infection by a lymphotropic virus.
    Glycobiology. 1999 Jun;9(6):557-69 PMID: 10336988
  38. TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity.
    J Immunol. 2000 Dec 1;165(11):6293-300 PMID: 11086065
  39. Anti-apoptotic strategies of lymphotropic viruses.
    Immunol Today. 1998 Oct;19(10):474-9 PMID: 9785672
  40. Regulation of death receptor-mediated apoptosis pathways.
    Int J Biochem Cell Biol. 2000 Nov-Dec;32(11-12):1123-36 PMID: 11137452
  41. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways.
    Mol Cell Biol. 1999 Oct;19(10):6742-53 PMID: 10490613
  42. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1).
    J Virol. 1998 Feb;72(2):1005-12 PMID: 9444993
  43. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.
    Immunity. 2000 Jun;12(6):611-20 PMID: 10894161
  44. Cell death in development.
    Cell. 1999 Jan 22;96(2):245-54 PMID: 9988219
  45. Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells.
    Eur J Immunol. 2000 Oct;30(10):2765-74 PMID: 11069056
  46. An induced proximity model for caspase-8 activation.
    J Biol Chem. 1998 Jan 30;273(5):2926-30 PMID: 9446604
  47. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling.
    Mol Cell Biol. 2001 Jun;21(12):3964-73 PMID: 11359904
  48. FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor.
    EMBO J. 2000 Mar 1;19(5):931-41 PMID: 10698935
  49. Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
    Annu Rev Biochem. 1999;68:383-424 PMID: 10872455
  50. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
    EMBO J. 1995 Nov 15;14(22):5579-88 PMID: 8521815
  51. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
    Cell. 1996 Jun 14;85(6):817-27 PMID: 8681377
  52. Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis.
    J Cell Biol. 1998 Jun 1;141(5):1243-53 PMID: 9606215
  53. Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
    Oncogene. 1999 Oct 14;18(42):5738-46 PMID: 10523854
  54. Casper is a FADD- and caspase-related inducer of apoptosis.
    Immunity. 1997 Jun;6(6):751-63 PMID: 9208847
  55. Biochemistry and function of the DISC.
    Trends Biochem Sci. 2001 Jul;26(7):452-3 PMID: 11440858
  56. The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
    J Exp Med. 1999 Oct 4;190(7):1025-32 PMID: 10510092
  57. Tumor necrosis factor receptor and Fas signaling mechanisms.
    Annu Rev Immunol. 1999;17:331-67 PMID: 10358762
  58. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
    J Biol Chem. 1997 Jul 11;272(28):17255-7 PMID: 9211860
  59. Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP.
    Eur J Immunol. 2000 Jan;30(1):155-63 PMID: 10602037
  60. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.
    J Natl Cancer Inst. 1999 Oct 20;91(20):1725-33 PMID: 10528022
  61. Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity.
    Nat Immunol. 2001 Apr;2(4):333-7 PMID: 11276204
  62. Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells.
    J Immunol. 1999 Aug 15;163(4):1839-44 PMID: 10438917
  63. Reduction of thymocyte numbers in transgenic mice expressing viral FLICE-inhibitory protein in a Fas-independent manner.
    Microbiol Immunol. 2000;44(4):289-97 PMID: 10832975
  64. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis.
    J Cell Biol. 2001 Feb 5;152(3):633-43 PMID: 11157988
  65. Apoptosis signaling by death receptors.
    Eur J Biochem. 1998 Jun 15;254(3):439-59 PMID: 9688254
  66. CD95(APO-1/Fas)-mediated apoptosis: live and let die.
    Adv Immunol. 1999;71:163-210 PMID: 9917913
  67. Cell surface sialylation plays a role in modulating sensitivity towards APO-1-mediated apoptotic cell death.
    Cell Death Differ. 1995 Jul;2(3):163-71 PMID: 17180039
  68. TRAIL: a molecule with multiple receptors and control mechanisms.
    Curr Opin Immunol. 1998 Oct;10(5):559-63 PMID: 9794836
  69. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
    Cell Death Differ. 1998 Apr;5(4):271-88 PMID: 10200473
  70. Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells.
    J Immunol. 2000 Sep 15;165(6):3023-30 PMID: 10975811
  71. FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis.
    J Exp Med. 1999 Dec 6;190(11):1679-88 PMID: 10587358
  72. Cytotoxic drugs and the CD95 pathway.
    Leukemia. 1999 Nov;13(11):1854-8 PMID: 10557062
  73. CD95's deadly mission in the immune system.
    Nature. 2000 Oct 12;407(6805):789-95 PMID: 11048730
  74. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing.
    J Exp Med. 1997 Dec 15;186(12):2045-50 PMID: 9396774
  75. Fas ligand mediates activation-induced cell death in human T lymphocytes.
    J Exp Med. 1995 Jan 1;181(1):71-7 PMID: 7528780
  76. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes.
    Immunity. 1999 Dec;11(6):763-70 PMID: 10626898
  77. Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein.
    J Virol. 2001 Mar;75(6):2938-45 PMID: 11222719
  78. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
    Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10717-22 PMID: 9380701
  79. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
    J Immunol. 1998 Oct 15;161(8):3936-42 PMID: 9780161
  80. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.
    J Exp Med. 1999 Oct 4;190(7):1033-8 PMID: 10510093
  81. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
    Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1172-6 PMID: 9037025
  82. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
    Immunity. 2000 Jun;12(6):599-609 PMID: 10894160
  83. Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus.
    J Virol. 2001 Feb;75(4):1857-63 PMID: 11160684
  84. Endothelial cell apoptosis induced by oxidized LDL is associated with the down-regulation of the cellular caspase inhibitor FLIP.
    J Biol Chem. 1998 Dec 11;273(50):33103-6 PMID: 9837872
  85. Programmed cell death (apoptosis) in cord blood lymphocytes.
    J Clin Immunol. 1997 Jan;17(1):63-73 PMID: 9049787
  86. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
    Immunity. 1998 Aug;9(2):267-76 PMID: 9729047
  87. Activation of NF-kappaB by FADD, Casper, and caspase-8.
    J Biol Chem. 2000 Apr 14;275(15):10838-44 PMID: 10753878
  88. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma.
    Cancer Res. 1999 Jun 1;59(11):2747-53 PMID: 10364001
  89. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
    Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11333-8 PMID: 9326610
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/MCB.21.24.8247-8254.2001
Published
2001-12-00
Pages
8247-54
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC99990
Subset
IM
External Links
PubMed source DOI: 10.1128/MCB.21.24.8247-8254.2001 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2