The synthesis of hyaluronic acid by sheep and rabbit articular cartilage in vitro.

The Biochemical journal ·Vol. 145 ·No. 2 ·1975-02-00 ·Pages 209-13

Gillard GC, Caterson B, Lowther DA

Abstract

Standard methods of glycosaminoglycan separation were used to confirm the presence of hyaluronic acid in sheep and rabbit articular cartilage. During incubation of carilage in vitro in the presence of [1-14 C]acetate, cartilage cells synthesize this macromolecule and, under the conditions used, it appears to have a shorter turnover time than chondroitin suplhate in the same tissue. The possible functions of hyaluronic acid in cartilage are discussed.

MeSH Terms

Acetates/metabolism Animals Cartilage, Articular/metabolism Chondroitin/metabolism Disaccharides/analysis Glycosaminoglycans/analysis Hyaluronic Acid/biosynthesis,isolation & purification In Vitro Techniques Lyases Papain Rabbits Sheep

Chemicals

Acetates Disaccharides Glycosaminoglycans Hyaluronic Acid Chondroitin Papain Lyases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gillard G C

Caterson B

Lowther D A

References (13)

13 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1450209

Published

1975-02-00

Pages

209-13

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1165209

Subset

External Links

PubMed source DOI: 10.1042/bj1450209 PMC Full Text View journal details

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The synthesis of hyaluronic acid by sheep and rabbit articular cartilage in vitro.

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