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PMID: 11556396 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster.

Virus genes ·Vol. 23 ·No. 1 ·2001-00-00 ·Pages 105-18

Penzes Z, Gonzalez JM, Calvo E, Izeta A, Smerdou C, Méndez A, Sanchez CM, Sola I, Almazan F, Enjuanes L

Abstract

The complete sequence (28580 nt) of the PUR46-MAD clone of the Purdue cluster of transmissible gastroenteritis coronavirus (TGEV) has been determined and compared with members of this cluster and other coronaviruses. The computing distances among their S gene sequences resulted in the grouping of these coronaviruses into four clusters, one of them exclusively formed by the Purdue viruses. Three new potential sequence motifs with homology to the alpha-subunit of the polymerase-associated nucleocapsid phosphoprotein of rinderpest virus, the Bowman-Birk type of proteinase inhibitors, and the metallothionein superfamily of cysteine rich chelating proteins have been identified. Comparison of the TGEV polymerase sequence with that of other RNA viruses revealed high sequence homology with the A-E domains of the palm subdomain of nucleic acid polymerases.

MeSH Terms
Amino Acid Sequence Animals Evolution, Molecular Genome, Viral Molecular Sequence Data Open Reading Frames Sequence Analysis, DNA Sequence Homology, Amino Acid Swine Transmissible gastroenteritis virus/classification,genetics,isolation & purification
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Penzes Z
Centro Nacional de Biotecnología, CSIC, Department of Molecular and Cell Biology, Cantoblaico, Madrid, Spain.
Gonzalez J M
Calvo E
Izeta A
Smerdou C
Méndez A
Sanchez C M
Sola I
Almazan F
Enjuanes L
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Article Info
Journal
Virus genes
Abbr.
Virus Genes
ISSN
0920-8569
DOI
10.1023/a:1011147832586
Published
2001-00-00
Pages
105-18
Language
English
Region
United States
NLM ID
8803967
PMCID
PMC7088808
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1011147832586 PMC Full Text View journal details
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