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PMID: 11547902 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

MUC1, the renaissance molecule.

Journal of mammary gland biology and neoplasia ·Vol. 6 ·No. 3 ·2001-07-00 ·Pages 339-53

Gendler SJ

Abstract

MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory, urinary and reproductive tracts. Although MUC1 was thought to be an epithelial-specific protein, it is now known to be expressed on a variety of hematopoietic cells as well. Mucins function in protection and lubrication of epithelial surfaces. Transmembrane mucins, which contain cytoplasmic tail domains, appear to have additional functions through their abilities to interact with many proteins involved in signal transduction and cell adhesion. The goal of this review is to highlight recent discoveries that suggest that MUC1 may be a multifunctional protein, located on the surfaces of cells as a sensor of the environment, poised to signal to the interior when things go awry.

MeSH Terms
Animals Breast Neoplasms/metabolism Female Humans Mammary Neoplasms, Experimental/metabolism Mucin-1/physiology
Chemicals
Mucin-1
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gendler S J
Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA. gendler.sandra@mayo.edu
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1011379725811
Email
gendler.sandra@mayo.edu
Published
2001-07-00
Pages
339-53
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NCI NIH HHS · CA64389 · United States
NCI NIH HHS · CA81703 · United States
NHLBI NIH HHS · HL07897 · United States
External Links
PubMed source DOI: 10.1023/a:1011379725811 View journal details
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