Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 8 ·1979-08-00 ·Pages 3774-8

Siegel MI, McConnell RT, Cuatrecasas P

Abstract

Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5,8,10,14-eicosatetraenoic acid.

MeSH Terms

Arachidonic Acids/metabolism Aspirin/pharmacology Blood Platelets/metabolism Humans Hydroxy Acids/metabolism Indomethacin/pharmacology Lipoxygenase Inhibitors Peroxidases/metabolism Salicylates/pharmacology Thrombin/metabolism

Chemicals

Arachidonic Acids Hydroxy Acids Lipoxygenase Inhibitors Salicylates Peroxidases Thrombin Aspirin Indomethacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Siegel M I

McConnell R T

Cuatrecasas P

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26 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.76.8.3774

Published

1979-08-00

Pages

3774-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC383916

Subset

External Links

PubMed source DOI: 10.1073/pnas.76.8.3774 PMC Full Text View journal details

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Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

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