Home LiteratureArticle Details
PMID: 11447209 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Evolutionary relationships among virulence-associated histidine kinases.

Infection and immunity ·Vol. 69 ·No. 8 ·2001-08-00 ·Pages 5207-11

Brinkman FS, Macfarlane EL, Warrener P, Hancock RE

Abstract

A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms. Phylogenetic analysis also identified a group of histidine kinases orthologous to the Streptomyces proteins that includes Pseudomonas aeruginosa GacS. We provide evidence that GacS is important for swarming motility, lipase production, and virulence in mice and had evolved to have partial functional overlaps with PhoQ, a less-related virulence-associated histidine kinase.

MeSH Terms
Animals Ascomycota/enzymology,genetics,pathogenicity Bacterial Proteins/genetics,physiology Candida albicans/enzymology,genetics,pathogenicity Evolution, Molecular Histidine Kinase Lipase/biosynthesis Mice Mice, Inbred C57BL Protein Kinases/genetics,physiology Protein Serine-Threonine Kinases Pseudomonas aeruginosa/enzymology,genetics,pathogenicity Saccharomyces cerevisiae Proteins Streptomyces/enzymology,genetics,pathogenicity Transcription Factors/genetics,physiology Virulence
Chemicals
Bacterial Proteins PhoQ protein, Bacteria Saccharomyces cerevisiae Proteins Transcription Factors PhoP protein, Bacteria Protein Kinases HSL1 protein, S cerevisiae Protein Serine-Threonine Kinases Histidine Kinase lemA protein, bacterial Lipase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brinkman F S
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Macfarlane E L
Warrener P
Hancock R E
References (16)
16 references, click to expand
  1. PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance.
    Mol Microbiol. 1999 Oct;34(2):305-16 PMID: 10564474
  2. Swarming by Pseudomonas syringae B728a requires gacS (lemA) and gacA but not the acyl-homoserine lactone biosynthetic gene ahlI.
    J Bacteriol. 1999 Jul;181(13):4133-6 PMID: 10383988
  3. Histidine kinase, two-component signal transduction proteins of Candida albicans and the pathogenesis of candidosis.
    Mycoses. 1999;42 Suppl 2:49-53 PMID: 10865904
  4. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
    Nature. 2000 Aug 31;406(6799):959-64 PMID: 10984043
  5. Role of Pseudomonas aeruginosa PhoP-phoQ in resistance to antimicrobial cationic peptides and aminoglycosides.
    Microbiology. 2000 Oct;146 ( Pt 10):2543-54 PMID: 11021929
  6. Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili.
    J Bacteriol. 2000 Nov;182(21):5990-6 PMID: 11029417
  7. Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli.
    J Biol Chem. 2001 Jan 5;276(1):225-31 PMID: 11022030
  8. Two-component systems in Pseudomonas aeruginosa: why so many?
    Trends Microbiol. 2000 Nov;8(11):498-504 PMID: 11121759
  9. A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome.
    Mol Microbiol. 1996 Jul;21(1):77-96 PMID: 8843436
  10. Antiendotoxin activity of cationic peptide antimicrobial agents.
    Infect Immun. 1996 Dec;64(12):4922-7 PMID: 8945527
  11. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase.
    Mol Microbiol. 1997 Apr;24(2):309-19 PMID: 9159518
  12. Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis.
    Mol Microbiol. 1998 May;28(3):449-61 PMID: 9632250
  13. A newly identified regulator is required for virulence and toxin production in Pseudomonas syringae.
    Mol Microbiol. 1998 Jun;28(5):917-29 PMID: 9663679
  14. The two-component hybrid kinase regulator CaNIK1 of Candida albicans.
    Microbiology. 1998 Oct;144 ( Pt 10):2715-29 PMID: 9802013
  15. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.
    Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2408-13 PMID: 10051655
  16. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans.
    J Bacteriol. 1999 Dec;181(23):7243-7 PMID: 10572127
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.69.8.5207-5211.2001
Published
2001-08-00
Pages
5207-11
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC98623
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.69.8.5207-5211.2001 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2