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PMID: 11438035 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction.

Arthritis research ·Vol. 3 ·No. 4 ·2001-00-00 ·Pages 200-6

Makarov SS

Abstract

The transcription factor NF-kappa B has been well recognized as a pivotal regulator of inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad involvement of NF-kappa B in other aspects of RA pathology, including development of T helper 1 responses, activation, abnormal apoptosis and proliferation of RA fibroblast-like synovial cells, and differentiation and activation of bone resorbing activity of osteoclasts. In agreement with this, studies in animal models of RA have demonstrated the high therapeutic efficacy of specific inhibitors of NF-kappa B pathway, indicating the feasibility of anti-NF-kappa B therapy for human disease.

MeSH Terms
Animals Arthritis, Rheumatoid/drug therapy,genetics,metabolism,pathology Disease Models, Animal Humans Hyperplasia Joints/pathology NF-kappa B/antagonists & inhibitors,genetics,metabolism Synovitis/genetics,metabolism,pathology
Chemicals
NF-kappa B
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Makarov S S
Center for Inflammatory Disorders, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7280, USA. smak@med.unc.edu
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Article Info
Journal
Arthritis research
Abbr.
Arthritis Res
ISSN
1465-9905
DOI
10.1186/ar300
Email
smak@med.unc.edu
Published
2001-00-00
Epub
2001-00-26
Pages
200-6
Language
English
Region
England
NLM ID
100913255
PMCID
PMC128895
Subset
IM
Grants
NIAMS NIH HHS · 5-P60-AR30701-14 · United States
NIAMS NIH HHS · AR/AI 44030 · United States
NIAMS NIH HHS · AR/AI 44564 · United States
External Links
PubMed source DOI: 10.1186/ar300 PMC Full Text
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