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PMID: 11422538 Published · ppublish English Journal Article Review

Biology of human papillomaviruses.

International journal of experimental pathology ·Vol. 82 ·No. 1 ·2001-02-00 ·Pages 15-33

McMurray HR, Nguyen D, Westbrook TF, McAnce DJ

Abstract

Human papillomaviruses (HPVs) cause squamous cancers of epithelial surfaces, of which genital cancers are the most common. In this article we have attempted to describe the properties and functions of the viral proteins of HPV type 16, a common cause of genital cancers, and have tried to suggest how their expression may lead to a dysregulated cell which may become malignant. These viruses are attempting to replicate in terminally differentiating keratinocytes and must stimulate G1 to S-phase progression for the replication of their genome. As part of the successful completion of replication and assembly of infectious virus particles, the virus needs at least partial differentiation to occur. Therefore, at the same time as differentiation is occurring, the nuclei of infected cells are in S-phase. While the mechanisms of action of the viral proteins are not completely understood, researchers are making progress and this article strives to bring together the conclusions from some of this work.

MeSH Terms
Adenosine Triphosphatases/metabolism Adult Apoptosis Carcinoma, Squamous Cell/metabolism,pathology,virology Cell Cycle Cell Death Cell Transformation, Viral Cyclins/metabolism Epithelium/metabolism,pathology,virology Female Genital Neoplasms, Female/metabolism,pathology,virology Genital Neoplasms, Male/metabolism,pathology,virology Histone Deacetylases/metabolism Humans Keratinocytes/metabolism,pathology,virology Male Middle Aged Oncogene Proteins, Viral/metabolism Papillomaviridae/physiology Papillomavirus E7 Proteins Protein Binding Receptors, Growth Factor/metabolism Repressor Proteins Retinoblastoma Protein/metabolism Transcription Factor AP-1/metabolism Transcription, Genetic Viral Envelope Proteins/physiology Virus Replication
Chemicals
Cyclins E6 protein, Human papillomavirus type 16 Oncogene Proteins, Viral Papillomavirus E7 Proteins Receptors, Growth Factor Repressor Proteins Retinoblastoma Protein Transcription Factor AP-1 Viral Envelope Proteins oncogene protein E5, Human papillomavirus type 16 oncogene protein E7, Human papillomavirus type 16 Histone Deacetylases Adenosine Triphosphatases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
McMurray H R
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Nguyen D
Westbrook T F
McAnce D J
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Article Info
Journal
International journal of experimental pathology
Abbr.
Int J Exp Pathol
ISSN
0959-9673
DOI
10.1046/j.1365-2613.2001.00177.x
Published
2001-02-00
Pages
15-33
Language
English
Region
England
NLM ID
9014042
PMCID
PMC2517699
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2613.2001.00177.x PMC Full Text View journal details
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