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PMID: 11413339 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity.

Journal of virology ·Vol. 75 ·No. 14 ·2001-07-00 ·Pages 6705-9

Harandi AM, Svennerholm B, Holmgren J, Eriksson K

Abstract

Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a protective gamma interferon-mediated immune response.

MeSH Terms
Animals Disease Models, Animal Herpes Genitalis/immunology,prevention & control,virology Herpesvirus 2, Human/immunology Immunity, Innate Interferon-gamma/deficiency,genetics,immunology Interleukin-12/deficiency,genetics,immunology Interleukin-18/deficiency,genetics,immunology Mice Mice, Inbred C57BL Mice, Knockout Vaccination
Chemicals
Interleukin-18 Interleukin-12 Interferon-gamma
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Harandi A M
Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10A, 413 46 Göteborg, Sweden.
Svennerholm B
Holmgren J
Eriksson K
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.14.6705-6709.2001
Published
2001-07-00
Pages
6705-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC114395
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.75.14.6705-6709.2001 PMC Full Text View journal details
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