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The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients.
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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood.
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Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells.
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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
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Analysis of the requirements for the induction of CD4+ T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody.
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Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.
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CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro.
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IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.
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CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade.
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Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis.
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CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.
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Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.
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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.
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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.
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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
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Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes.
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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.
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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood.
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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
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