Home LiteratureArticle Details
PMID: 11390442 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Certified professionals: CD4(+)CD25(+) suppressor T cells.

The Journal of experimental medicine ·Vol. 193 ·No. 11 ·2001-06-04 ·Pages F41-6

Shevach EM

Abstract

暂无摘要

MeSH Terms
Animals CD4 Antigens/analysis Humans Immune Tolerance Receptors, Interleukin-2/analysis T-Lymphocytes, Regulatory/physiology Thymus Gland/cytology Transplantation Immunology
Chemicals
CD4 Antigens Receptors, Interleukin-2
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Shevach E M
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ems1@mail.nih.gov
References (32)
32 references, click to expand
  1. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
    Int Immunol. 1998 Dec;10(12):1969-80 PMID: 9885918
  2. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.
    J Exp Med. 1998 Jul 20;188(2):287-96 PMID: 9670041
  3. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.
    J Exp Med. 2001 Jun 4;193(11):1295-302 PMID: 11390436
  4. Anergic T cells inhibit the antigen-presenting function of dendritic cells.
    J Immunol. 2000 Aug 1;165(3):1175-81 PMID: 10903714
  5. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients.
    J Exp Med. 1996 Dec 1;184(6):2393-8 PMID: 8976193
  6. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood.
    J Exp Med. 2001 Jun 4;193(11):1303-10 PMID: 11390437
  7. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.
    J Immunol. 2000 Sep 15;165(6):3105-10 PMID: 10975823
  8. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells.
    J Autoimmun. 2001 Mar;16(2):115-23 PMID: 11247637
  9. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
    J Immunol. 1995 Aug 1;155(3):1151-64 PMID: 7636184
  10. CD4+CD25high regulatory cells in human peripheral blood.
    J Immunol. 2001 Aug 1;167(3):1245-53 PMID: 11466340
  11. Analysis of the requirements for the induction of CD4+ T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody.
    J Immunol. 2000 Jan 15;164(2):612-22 PMID: 10623802
  12. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.
    Eur J Immunol. 2001 Apr;31(4):1247-54 PMID: 11298351
  13. CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro.
    Eur J Immunol. 1998 Nov;28(11):3435-47 PMID: 9842886
  14. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.
    Int Immunol. 1998 Apr;10(4):371-8 PMID: 9620592
  15. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.
    J Immunol. 1999 May 1;162(9):5317-26 PMID: 10228007
  16. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population.
    Eur J Immunol. 2001 Apr;31(4):1122-31 PMID: 11298337
  17. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.
    J Immunol. 2001 Mar 15;166(6):3789-96 PMID: 11238621
  18. Regulatory T cells in autoimmmunity*.
    Annu Rev Immunol. 2000;18:423-49 PMID: 10837065
  19. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific.
    J Immunol. 2000 Jan 1;164(1):183-90 PMID: 10605010
  20. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade.
    J Exp Med. 2001 Jun 4;193(11):1311-8 PMID: 11390438
  21. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.
    J Exp Med. 1996 Jun 1;183(6):2669-74 PMID: 8676088
  22. Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis.
    J Immunol. 2000 May 15;164(10):5499-507 PMID: 10799918
  23. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.
    J Immunol. 1998 Feb 1;160(3):1212-8 PMID: 9570536
  24. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.
    J Exp Med. 2000 Nov 6;192(9):1213-22 PMID: 11067871
  25. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
    J Exp Med. 2000 Jul 17;192(2):295-302 PMID: 10899916
  26. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.
    Nat Immunol. 2001 Apr;2(4):301-6 PMID: 11276200
  27. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.
    Nature. 1997 Oct 16;389(6652):737-42 PMID: 9338786
  28. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
    J Exp Med. 1996 Aug 1;184(2):387-96 PMID: 8760792
  29. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes.
    J Exp Med. 1999 Jan 18;189(2):279-88 PMID: 9892610
  30. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.
    J Exp Med. 1999 Oct 4;190(7):995-1004 PMID: 10510089
  31. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood.
    J Exp Med. 2001 Jun 4;193(11):1285-94 PMID: 11390435
  32. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
    J Exp Med. 2000 Jul 17;192(2):303-10 PMID: 10899917
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
2001-06-04
Pages
F41-6
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2193387
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com