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PMID: 11376124 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The IGF axis and hepatocarcinogenesis.

Molecular pathology : MP ·Vol. 54 ·No. 3 ·2001-06-00 ·Pages 138-44

Scharf JG, Dombrowski F, Ramadori G

Abstract

Deregulation of the insulin-like growth factor (IGF) axis, including the autocrine production of IGFs, IGF binding proteins (IGFBPs), IGFBP proteases, and the expression of the IGF receptors, has been identified in the development of hepatocellular carcinoma (HCC). Characteristic alterations detected in HCC and hepatoma cell lines comprise the increased expression of IGF-II and the IGF-I receptor (IGF-IR), which have emerged as crucial events in malignant transformation and the growth of tumours. Alterations of IGFBP production and the proteolytic degradation of IGFBPs resulting in an excess of bioactive IGFs, as well as the defective function of the IGF degrading IGF-II/mannose 6-phosphate receptor (IGF-II/M6PR), may further potentiate the mitogenic effects of IGFs in the development of HCC.

MeSH Terms
Animals Carcinoma, Hepatocellular/metabolism Cell Transformation, Neoplastic/metabolism Chickens Endopeptidases/metabolism Humans Insulin-Like Growth Factor Binding Proteins/metabolism Insulin-Like Growth Factor I/metabolism Insulin-Like Growth Factor II/metabolism Liver Neoplasms/metabolism Mice Rats Receptor, IGF Type 1/metabolism Receptor, IGF Type 2/metabolism Receptor, Insulin/physiology Signal Transduction/physiology Tumor Cells, Cultured
Chemicals
Insulin-Like Growth Factor Binding Proteins Receptor, IGF Type 2 Insulin-Like Growth Factor I Insulin-Like Growth Factor II Receptor, IGF Type 1 Receptor, Insulin Endopeptidases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Scharf J G
Department of Medicine, Division of Gastroenterology and Endocrinology, Georg-August-Universität, D-37075 Göttingen, Germany. jscharf@med.uni-goettingen.de
Dombrowski F
Ramadori G
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Article Info
Journal
Molecular pathology : MP
Abbr.
Mol Pathol
ISSN
1366-8714
DOI
10.1136/mp.54.3.138
Email
jscharf@med.uni-goettingen.de
Published
2001-06-00
Pages
138-44
Language
English
Region
England
NLM ID
9706282
PMCID
PMC1187051
Subset
IM
External Links
PubMed source DOI: 10.1136/mp.54.3.138 PMC Full Text
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