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PMID: 2458716 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor.

The Biochemical journal ·Vol. 252 ·No. 3 ·1988-06-15 ·Pages 795-9

Causin C, Waheed A, Braulke T, Junghans U, Maly P, Humbel RE, von Figura K

Abstract

Human serum and urine contain polypeptides which bind mannose 6-phosphate (M6P) and insulin-like growth factor II (IGF II) and crossreact with antibodies against the M6P/IGF II receptor. These polypeptides are considered to be fragments of the M6P/IGF II receptor. The major Mr approx. 205,000 fragment in serum and urine is about 10 kDa smaller in size than the membrane-associated receptor and is accompanied by minor forms with Mr values ranging from 104,000 to 180,000. The presence of receptor fragments in biological fluids indicates that shedding is one of the mechanisms contributing to the turnover of the M6P/IGF II receptor and that receptor fragments are part of the heterogenous group of serum proteins whic bind IGF II.

MeSH Terms
Carrier Proteins/blood,immunology,metabolism,urine Cross Reactions Electrophoresis, Polyacrylamide Gel Hexosephosphates/metabolism Humans Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor II/metabolism Lectins, C-Type Mannose Receptor Mannose-Binding Lectins Mannosephosphates/metabolism Peptide Fragments/immunology Receptor, Insulin/immunology,metabolism Receptors, Cell Surface Receptors, Immunologic/immunology,metabolism Receptors, Somatomedin Somatomedins/metabolism
Chemicals
Carrier Proteins Hexosephosphates Insulin-Like Growth Factor Binding Proteins Lectins, C-Type Mannose Receptor Mannose-Binding Lectins Mannosephosphates Peptide Fragments Receptors, Cell Surface Receptors, Immunologic Receptors, Somatomedin Somatomedins mannose-6-phosphate Insulin-Like Growth Factor II Receptor, Insulin
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Causin C
Biochemie II, Georg-August-Universität Göttingen, Federal Republic of Germany.
Waheed A
Braulke T
Junghans U
Maly P
Humbel R E
von Figura K
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2520795
Published
1988-06-15
Pages
795-9
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1149217
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2520795 PMC Full Text View journal details
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