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PMID: 11359913 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses.

Molecular and cellular biology ·Vol. 21 ·No. 12 ·2001-06-00 ·Pages 4067-74

Xu S, Lam KP

Abstract

B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate cellular proliferation. BAFF in particular has been shown to influence B-cell survival and activation, and transgenic mice overexpressing BAFF have a lupus-like autoimmune disorder. We have inactivated BCMA in the mouse germ line. BCMA(-/-) mice have normal B-cell development, and the life span of mutant B lymphocytes is comparable to that of wild-type B cells. The humoral immune responses of BCMA(-/-) mice to T-cell-independent antigens as well as high and low doses of T-cell-dependent antigens are also intact. In addition, mutant mice have normal splenic architecture, and germinal centers are formed during an ongoing immune response. These data suggest a functional redundancy of BCMA in B-cell physiology that is probably due to the presence of TACI, another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL.

MeSH Terms
Animals Antibody Formation B-Cell Activating Factor B-Cell Maturation Antigen B-Lymphocytes/cytology,immunology,metabolism Base Sequence Cell Differentiation Cellular Senescence DNA Primers/genetics Membrane Proteins/metabolism Mice Mice, Inbred C57BL Mice, Knockout Neuropeptides/metabolism Nuclear Proteins/metabolism Protein Binding Receptors, Tumor Necrosis Factor/genetics,immunology,metabolism Spleen/cytology,immunology Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor-alpha/metabolism
Chemicals
B-Cell Activating Factor B-Cell Maturation Antigen DNA Primers Membrane Proteins Neuropeptides Nuclear Proteins Receptors, Tumor Necrosis Factor Tnfrsf13b protein, mouse Tnfrsf17 protein, mouse Tnfsf13b protein, mouse Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor-alpha
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Xu S
Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.
Lam K P
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37 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/MCB.21.12.4067-4074.2001
Published
2001-06-00
Pages
4067-74
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC87068
Subset
IM
External Links
PubMed source DOI: 10.1128/MCB.21.12.4067-4074.2001 PMC Full Text View journal details
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