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PMID: 10960320 Published · ppublish English Journal Article

Immunology. Lymphocyte survival--ignorance is BLys.

Science (New York, N.Y.) ·Vol. 289 ·No. 5481 ·2000-08-11 ·Pages 883-4

Laâbi Y, Strasser A

Abstract

As if the TNF receptor and ligand superfamily was not big enough, two new receptors and their ligands have now been added to it. As Laâbi and Strasser explain in their Perspective, the receptors BCMA and TACI and their ligands BAFF/BLys and APRIL, respectively, are important for B lymphocyte survival, proliferation, and differentiation.

MeSH Terms
Animals Apoptosis B-Cell Activating Factor B-Cell Maturation Antigen B-Lymphocytes/cytology,immunology,metabolism CD40 Ligand Cell Differentiation Cell Division Cell Survival Cytokines/metabolism Humans Ligands Lymphocyte Activation Membrane Glycoproteins/metabolism Membrane Proteins/metabolism Mice NF-kappa B/metabolism Neoplasms/etiology,pathology Receptors, Antigen, B-Cell/metabolism Receptors, Tumor Necrosis Factor/metabolism Signal Transduction Transcription Factors/metabolism Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha/metabolism
Chemicals
B-Cell Activating Factor B-Cell Maturation Antigen Cytokines Ligands Membrane Glycoproteins Membrane Proteins NF-kappa B Receptors, Antigen, B-Cell Receptors, Tumor Necrosis Factor TNFRSF13B protein, human TNFRSF17 protein, human TNFSF13 protein, human TNFSF13B protein, human Tnfrsf13b protein, mouse Tnfrsf17 protein, mouse Tnfsf13 protein, mouse Tnfsf13b protein, mouse Transcription Factors Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha CD40 Ligand
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Laâbi Y
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Victoria, Australia. laabi@wehi.edu.au
Strasser A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
2000-08-11
Pages
883-4
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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