Abstract
As if the TNF receptor and ligand superfamily was not big enough, two new receptors and their ligands have now been added to it. As Laâbi and Strasser explain in their Perspective, the receptors BCMA and TACI and their ligands BAFF/BLys and APRIL, respectively, are important for B lymphocyte survival, proliferation, and differentiation.
MeSH Terms
Animals
Apoptosis
B-Cell Activating Factor
B-Cell Maturation Antigen
B-Lymphocytes/cytology,immunology,metabolism
CD40 Ligand
Cell Differentiation
Cell Division
Cell Survival
Cytokines/metabolism
Humans
Ligands
Lymphocyte Activation
Membrane Glycoproteins/metabolism
Membrane Proteins/metabolism
Mice
NF-kappa B/metabolism
Neoplasms/etiology,pathology
Receptors, Antigen, B-Cell/metabolism
Receptors, Tumor Necrosis Factor/metabolism
Signal Transduction
Transcription Factors/metabolism
Transmembrane Activator and CAML Interactor Protein
Tumor Necrosis Factor Ligand Superfamily Member 13
Tumor Necrosis Factor-alpha/metabolism
Chemicals
B-Cell Activating Factor
B-Cell Maturation Antigen
Cytokines
Ligands
Membrane Glycoproteins
Membrane Proteins
NF-kappa B
Receptors, Antigen, B-Cell
Receptors, Tumor Necrosis Factor
TNFRSF13B protein, human
TNFRSF17 protein, human
TNFSF13 protein, human
TNFSF13B protein, human
Tnfrsf13b protein, mouse
Tnfrsf17 protein, mouse
Tnfsf13 protein, mouse
Tnfsf13b protein, mouse
Transcription Factors
Transmembrane Activator and CAML Interactor Protein
Tumor Necrosis Factor Ligand Superfamily Member 13
Tumor Necrosis Factor-alpha
CD40 Ligand
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Laâbi Y
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Victoria, Australia. laabi@wehi.edu.au
Strasser A