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The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.
J Biol Chem. 1999 Dec 17;274(51):36328-34
PMID: 10593924
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Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin.
Infect Immun. 1999 Aug;67(8):4223-30
PMID: 10417195
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Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.
Science. 2000 Feb 4;287(5454):860-4
PMID: 10657301
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Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor.
Mol Cell Biol. 2000 Apr;20(8):2734-42
PMID: 10733576
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Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration.
J Cell Physiol. 2000 Jul;184(1):118-30
PMID: 10825241
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In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.
Cancer Res. 2000 Jun 1;60(11):3096-104
PMID: 10850462
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The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin.
J Biol Chem. 2000 Jun 16;275(24):18337-43
PMID: 10751402
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Regulation of no synthesis induced by inflammatory mediators in RAW264.7 cells: collagen prevents inhibition by osteopontin.
Cytokine. 2000 May;12(5):450-7
PMID: 10857758
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Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).
J Exp Med. 2000 Jun 19;191(12):2053-64
PMID: 10859330
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Osteopontin is induced by nitric oxide in RAW 264.7 cells.
IUBMB Life. 2000 Mar;49(3):217-21
PMID: 10868913
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Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection.
Am J Pathol. 2000 Jul;157(1):37-42
PMID: 10880373
-
Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification.
J Biol Chem. 2000 Jun 30;275(26):20197-203
PMID: 10766759
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Analysis of the alpha4beta1 integrin-osteopontin interaction.
Exp Cell Res. 2000 Aug 1;258(2):342-51
PMID: 10896785
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Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
Arthritis Rheum. 2000 Jul;43(7):1597-605
PMID: 10902765
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Phosphate is a specific signal for induction of osteopontin gene expression.
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8352-7
PMID: 10890885
-
Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model: effect on type I collagen and alkaline phosphatase genes.
Calcif Tissue Int. 2000 Aug;67(2):163-72
PMID: 10920222
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Lack of in vivo function of osteopontin in experimental anti-GBM nephritis.
J Am Soc Nephrol. 2000 Sep;11(9):1647-55
PMID: 10966489
-
Osteopontin.
Crit Rev Oral Biol Med. 2000;11(3):279-303
PMID: 11021631
-
Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells.
J Leukoc Biol. 2000 Oct;68(4):495-502
PMID: 11037970
-
Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone.
Endocrinology. 2001 Mar;142(3):1325-32
PMID: 11181551
-
Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin.
J Exp Med. 2001 Feb 5;193(3):399-404
PMID: 11157060
-
Osteopontin: an intrinsic inhibitor of inflammation in cartilage.
Arthritis Rheum. 2001 Mar;44(3):578-84
PMID: 11263772
-
Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation.
Int J Exp Pathol. 2000 Dec;81(6):373-90
PMID: 11298186
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Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: early responses of osteocalcin and type I collagen.
Connect Tissue Res. 2001 Oct;42(2):135-48
PMID: 11718468
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Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone.
J Bone Miner Res. 1995 Nov;10(11):1666-80
PMID: 8592943
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Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.
Am J Pathol. 1996 Jul;149(1):293-305
PMID: 8686754
-
Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures.
J Cell Physiol. 1997 Feb;170(2):174-81
PMID: 9009146
-
Altered wound healing in mice lacking a functional osteopontin gene (spp1).
J Clin Invest. 1998 Apr 1;101(7):1468-78
PMID: 9525990
-
Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin.
Exp Cell Res. 1998 Jul 10;242(1):351-60
PMID: 9665832
-
CD44 occupancy prevents macrophage multinucleation.
J Cell Biol. 1998 Nov 2;143(3):837-47
PMID: 9813101
-
Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue.
Am J Physiol. 1998 Dec;275(6 Pt 2):H2258-65
PMID: 9843827
-
CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.
Cancer Res. 1999 Jan 1;59(1):219-26
PMID: 9892210
-
Osteopontin expression and function: role in bone remodeling.
J Cell Biochem Suppl. 1998;30-31:92-102
PMID: 9893260
-
Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro.
J Immunol. 1999 Jan 15;162(2):1024-31
PMID: 9916729
-
Osteopontin function in pathology: lessons from osteopontin-deficient mice.
Exp Nephrol. 1999 Mar-Apr;7(2):103-13
PMID: 10213864
-
Role of osteopontin in bone remodeling caused by mechanical stress.
J Bone Miner Res. 1999 Jun;14(6):839-49
PMID: 10352091
-
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption.
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8156-60
PMID: 10393964
-
Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.
J Clin Invest. 2000 Jan;105(1):21-34
PMID: 10619858