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PMID: 11298186 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation.

International journal of experimental pathology ·Vol. 81 ·No. 6 ·2000-12-00 ·Pages 373-90

O'Regan A, Berman JS

Abstract

Osteopontin (Opn) is a secreted adhesive, glycosylated phosphoprotein that contains the arginine-glycine-aspartic acid (RGD) cell-binding sequence that is found in many extracellular matrix (ECM) proteins (for a review of Opn see References Denhardt & Guo 1993; Patarca et al. 1993; Rittling & Denhardt 1999). Since its initial description in 1979 as a secreted protein associated with malignant transformation, Opn has been independently discovered by investigators from diverse scientific disciplines, and has been associated with a remarkable range of pathologic responses. Opn is an important bone matrix protein, where it is thought to mediate adhesion of osteoclasts to resorbing bone. However, studies from the past decade have identified an alternative role for Opn as a key cytokine regulating tissue repair and inflammation. Recent work by our laboratory and that of others has underlined the importance of Opn as a pivotal cytokine in the cellular immune response. Despite this Opn is not well known to the immunologist. In this review we will focus on studies that pertain to the role of Opn in cell-mediated and granulomatous inflammation.

MeSH Terms
Animals Calcinosis Cell Adhesion Chemotaxis, Leukocyte Cytokines/chemistry,genetics,physiology Disease Models, Animal Fibrosis Granulomatous Disease, Chronic/immunology Humans Immunity, Cellular Inflammation Mediators/chemistry,physiology Lymphocytes/immunology Macrophages/metabolism Mice Mice, Knockout Nitric Oxide/metabolism Osteopontin Receptors, Cytokine/metabolism Sialoglycoproteins/chemistry,genetics,physiology Wound Healing
Chemicals
Cytokines Inflammation Mediators Receptors, Cytokine SPP1 protein, human Sialoglycoproteins Spp1 protein, mouse Osteopontin Nitric Oxide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
O'Regan A
The Pulmonary Center, Pulmonary and Critical Care Section, Boston University School of Medicine, USA.
Berman J S
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Article Info
Journal
International journal of experimental pathology
Abbr.
Int J Exp Pathol
ISSN
0959-9673
DOI
10.1046/j.1365-2613.2000.00163.x
Published
2000-12-00
Pages
373-90
Language
English
Region
England
NLM ID
9014042
PMCID
PMC2517746
Subset
IM
Grants
NHLBI NIH HHS · HL63339 · United States
NHLBI NIH HHS · K08 HL004343 · United States
NHLBI NIH HHS · R01 HL063339 · United States
NHLBI NIH HHS · HL04343 · United States
NHLBI NIH HHS · P50-HL56386 · United States
External Links
PubMed source DOI: 10.1046/j.1365-2613.2000.00163.x PMC Full Text View journal details
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