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PMID: 11312356 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus).

Journal of virology ·Vol. 75 ·No. 10 ·2001-05-00 ·Pages 4843-53

Paulose-Murphy M, Ha NK, Xiang C, Chen Y, Gillim L, Yarchoan R, Meltzer P, Bittner M, Trent J, Zeichner S

Abstract

Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV-8.

MeSH Terms
Cell Line Gene Expression Profiling Gene Expression Regulation, Viral Genome, Viral Herpesvirus 8, Human/genetics Humans Transcription, Genetic
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Paulose-Murphy M
HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Ha N K
Xiang C
Chen Y
Gillim L
Yarchoan R
Meltzer P
Bittner M
Trent J
Zeichner S
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.10.4843-4853.2001
Published
2001-05-00
Pages
4843-53
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC114239
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.75.10.4843-4853.2001 PMC Full Text View journal details
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