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PMID: 11271788 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma.

Journal of clinical pathology ·Vol. 54 ·No. 1 ·2001-01-00 ·Pages 42-7

Pukkila MJ, Virtaniemi JA, Kumpulainen EJ, Pirinen RT, Johansson RT, Valtonen HJ, Juhola MT, Kosma VM

Abstract

To investigate the expression of alpha, beta, and gamma catenins in oropharyngeal and hypopharyngeal squamous cell carcinoma and their relations to each other, as well as to clinical data, tumour differentiation, and prognosis. Primary tumours for analysis were obtained from 138 patients diagnosed with squamous cell carcinoma of the oropharynx or hypopharynx between 1975 and 1998 in eastern Finland. Immunohistochemistry was used to evaluate the expression of alpha, beta, and gamma catenins. The expression patterns of all catenins were related to clinical data and survival. The expression patterns of all three catenins were significantly interrelated. Reduced gamma catenin expression was significantly associated with poor histological differentiation. No association was found between alpha or beta catenin expression and clinicopathological characteristics. In univariate analysis, patients whose tumours had nuclear beta catenin expression had shorter overall survival than patients with no nuclear expression. In Cox multivariate analysis, nuclear beta catenin expression, tumour status (T class), and Karnofsky performance index were independent prognostic factors of overall survival. Reduced expression of gamma catenin is associated with dedifferentiation in primary squamous cell carcinoma of the oropharynx and hypopharynx. The fact that nuclear beta catenin expression independently predicts short overall survival suggests that it might be a valuable prognostic marker in pharyngeal squamous cell carcinoma.

MeSH Terms
Adult Aged Aged, 80 and over Biomarkers, Tumor/metabolism Carcinoma, Squamous Cell/metabolism,pathology Cell Differentiation Cell Nucleus/metabolism Cytoskeletal Proteins/metabolism Female Follow-Up Studies Humans Hypopharyngeal Neoplasms/metabolism,pathology Immunoenzyme Techniques Karnofsky Performance Status Male Middle Aged Neoplasm Proteins/metabolism Oropharyngeal Neoplasms/metabolism,pathology Prognosis Survival Rate Trans-Activators beta Catenin
Chemicals
Biomarkers, Tumor CTNNB1 protein, human Cytoskeletal Proteins Neoplasm Proteins Trans-Activators beta Catenin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Pukkila M J
Department of Otorhinolaryngology, University of Kuopio, Kuopio University Hospital, PO Box 1777, FIN-70211, Kuopio, Finland.
Virtaniemi J A
Kumpulainen E J
Pirinen R T
Johansson R T
Valtonen H J
Juhola M T
Kosma V M
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.54.1.42
Published
2001-01-00
Pages
42-7
Language
English
Region
England
NLM ID
0376601
PMCID
PMC1731271
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.54.1.42 PMC Full Text View journal details
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