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PMID: 11245277 Published · ppublish English Journal Article Review

Angiogenesis, metastasis, and endogenous inhibition.

Journal of neuro-oncology ·Vol. 50 ·No. 1-2 ·2000-00-00 ·Pages 173-80

Kirsch M, Schackert G, Black PM

Abstract

Angiogenesis and the development of metastases are intrinsically connected. Experimental data suggest that establishment and growth of metastases are influenced by soluble factors secreted from the originating solid tumor. Among these factors are so-called endogenous inhibitors of angiogenesis which keep metastasis in a non-proliferating quiescent state. For a number of tumors it has been shown that this dormant state is mediated through inhibition of angiogenesis. This dormant state is characterized by normal proliferation, increased apoptosis, and insufficient neo-vascularization. Removal of inhibiting anti-angiogenic factors led to growth of dormant metastases. A number of endogenous inhibitors have been identified and have shown success in experimental therapeutic trials. This might be of special interest for the treatment of cerebral metastases which are the most common type of malignant brain tumors. Similar to the spread of metastases, it is known that single glioma cells can be found in distant parts of the brain. While local recurrence is a common phenomenon in glioma, formation of clinical apparent distant metastasis occurs rarely. Several lines of evidence suggest that growth inhibition of remote glioma cells may be mediated by an endogenous inhibitory mechanism.

MeSH Terms
Angiostatins Animals Brain Neoplasms/blood supply,pathology,secondary Collagen/physiology Disease Progression Endostatins Glioma/blood supply,pathology Humans Mice Mice, Nude Neoplasm Metastasis/physiopathology Neovascularization, Pathologic/physiopathology Peptide Fragments/physiology Plasminogen/physiology Time Factors
Chemicals
Endostatins Peptide Fragments Angiostatins Plasminogen Collagen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kirsch M
Klinik und Poliklinik für Neurochirurgie, Technische Universität Dresden, Germany. matthias.kirsch@mailbox.tu-dresden.de
Schackert G
Black P M
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Article Info
Journal
Journal of neuro-oncology
Abbr.
J Neurooncol
ISSN
0167-594X
DOI
10.1023/a:1006453428013
Email
matthias.kirsch@mailbox.tu-dresden.de
Published
2000-00-00
Pages
173-80
Language
English
Region
United States
NLM ID
8309335
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1006453428013 View journal details
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