Isolation of a tumor factor responsible for angiogenesis.

The Journal of experimental medicine ·Vol. 133 ·No. 2 ·1971-02-01 ·Pages 275-88

Folkman J, Merler E, Abernathy C, Williams G

Abstract

Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.

MeSH Terms

Animals Blood Vessels/growth & development Capillaries/growth & development Carcinoma 256, Walker/metabolism Carcinoma, Hepatocellular/metabolism Humans Liver Neoplasms/metabolism Melanoma/metabolism Mice Mitosis Neoplasm Transplantation Neoplasms/metabolism Neuroblastoma/metabolism Proteins RNA Rats Wilms Tumor/metabolism

Chemicals

Proteins RNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Folkman J

Merler E

Abernathy C

Williams G

References (6)

6 references, click to expand

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A new method for the isolation of ribonucleic acids from mammalian tissues.
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H-2 components and cellular membranes: distinctions between plasma membrane and endoplasmic reticulum governed by the H-2 region in the mouse.
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The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour.
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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.133.2.275

Published

1971-02-01

Pages

275-88

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138906

Subset

External Links

PubMed source DOI: 10.1084/jem.133.2.275 PMC Full Text View journal details

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Isolation of a tumor factor responsible for angiogenesis.

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