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PMID: 11152491 Published · ppublish English Journal Article

Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication.

Journal of virology ·Vol. 75 ·No. 3 ·2001-02-00 ·Pages 1186-94

Zimmermann W, Broll H, Ehlers B, Buhk HJ, Rosenthal A, Goltz M

Abstract

Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus of cattle. The complete long unique coding region (LUR) of BoHV-4 strain 66-p-347 was determined by a shotgun approach. Together with the previously published noncoding terminal repeats, the entire genome sequence of BoHV-4 is now available. The LUR consists of 108,873 bp with an overall G+C content of 41.4%. At least 79 open reading frames (ORFs) are present in this coding region, 17 of them unique to BoHV-4. In contrast to herpesvirus saimiri and human herpesvirus 8, BoHV-4 has a reduced set of ORFs homologous to cellular genes. Gene arrangement as well as phylogenetic analysis confirmed that BoHV-4 is a member of the genus Rhadinovirus. In addition, an origin of replication (ori) in the genome of BoHV-4 was identified by DpnI assays. A minimum of 1.69 kbp located between ORFs 69 and 71 was sufficient to act as a cis signal for replication.

MeSH Terms
Animals Cattle Cloning, Molecular DNA Replication DNA, Viral/chemistry Genome, Viral Open Reading Frames Phylogeny Rhadinovirus/classification,genetics Virus Replication
Chemicals
DNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zimmermann W
Department of Genetic Analysis, Genome Sequencing Centre, Institut für Molekulare Biotechnologie, 07745 Jena, Robert Koch-Institut, 13353 Berlin, Germany.
Broll H
Ehlers B
Buhk H J
Rosenthal A
Goltz M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.3.1186-1194.2001
Published
2001-02-00
Pages
1186-94
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC114024
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.75.3.1186-1194.2001 PMC Full Text View journal details
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