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PMID: 7871762 Published · ppublish English Journal Article

Glycoprotein B of bovine herpesvirus type 4: its phylogenetic relationship to gB equivalents of the herpesviruses.

Virus genes ·Vol. 9 ·No. 1 ·1994-09-00 ·Pages 53-9

Goltz M, Broll H, Mankertz A, Weigelt W, Ludwig H, Buhk HJ, Borchers K

Abstract

In order to estimate the phylogenetic relationship of BHV-4 among the herpesviruses, we have cloned and sequenced its glycoprotein B (gB). The 2.6 kb open reading frame codes for a 874 amino acid long protein. The comparison of its deduced amino acid sequence with those of its counterparts in 19 distinct herpesviruses groups BHV-4 into the gamma-herpesvirinae. The calculation of an evolutionary tree emphasized that BHV-4 is more closely related to herpesvirus saimiri (HVS) than to Epstein-Barr virus (EBV). However, in contrast to EBV and HVS, the gB of BHV-4 contains a putative protease cleavage site and 20 potential N-glycosylation sites. The alignment of the amino acid sequences revealed that 10 cysteine and 7 proline residues, as well as the motifs SPF and GQLG, were completely conserved among the 20 investigated gBs.

Related Genes
gB
MeSH Terms
Amino Acid Sequence Animals Base Sequence Binding Sites Cattle Cloning, Molecular Consensus Sequence DNA, Viral/genetics Gammaherpesvirinae/classification,genetics Genes, Viral Glycosylation Herpesvirus 2, Saimiriine/genetics Herpesvirus 4, Human/genetics Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Viral Envelope Proteins/chemistry,genetics
Chemicals
DNA, Viral Viral Envelope Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Goltz M
Robert Koch-Institut, Freien Universität Berlin, Germany.
Broll H
Mankertz A
Weigelt W
Ludwig H
Buhk H J
Borchers K
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Article Info
Journal
Virus genes
Abbr.
Virus Genes
ISSN
0920-8569
DOI
10.1007/BF01703435
Published
1994-09-00
Pages
53-9
Language
English
Region
United States
NLM ID
8803967
Subset
IM
Databases
GENBANK
Z15044
External Links
PubMed source DOI: 10.1007/BF01703435 View journal details
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