Home LiteratureArticle Details
PMID: 11042146 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10.

Genome research ·Vol. 10 ·No. 10 ·2000-10-00 ·Pages 1463-7

Pletcher MT, Roe BA, Chen F, Do T, Do A, Malaj E, Reeves RH

Abstract

During evolution, chromosomes are rearranged and become fixed into new patterns in new species. The relatively conservative nature of this process supports predictions of the arrangement of ancestral mammalian chromosomes, but the basis for these rearrangements is unknown. Physical mapping of mouse chromosome 10 (MMU 10) previously identified a 380-kb region containing the junction of material represented in human on chromosomes 21 (HSA 21) and 22 (HSA 22) that occurred in the evolutionary lineage of the mouse. Here, acquisition of 275 kb of mouse genomic sequence from this region and comparative sequence analysis with HSA 21 and HSA 22 narrowed the junction from 380 kb to 18 kb. The minimal junction region on MMU 10 contains a variety of repeats, including an L32-like ribosomal element and low-copy sequences found on several mouse chromosomes and represented in the mouse EST database. Sequence level analysis of an interchromosomal rearrangement during evolution has not been reported previously.

MeSH Terms
Animals Chromosomes/chemistry,genetics,metabolism Cloning, Molecular/methods Contig Mapping/methods Evolution, Molecular Gene Frequency/genetics Genomic Library Humans Mice Molecular Sequence Data Open Reading Frames Physical Chromosome Mapping/methods Recombination, Genetic Sequence Analysis, DNA/methods Transcription, Genetic
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Pletcher M T
Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
Roe B A
Chen F
Do T
Do A
Malaj E
Reeves R H
References (20)
20 references, click to expand
  1. Chromosome 22-specific low copy repeats and the 22q11.2 deletion syndrome: genomic organization and deletion endpoint analysis.
    Hum Mol Genet. 2000 Mar 1;9(4):489-501 PMID: 10699172
  2. A brief history of human autosomes.
    Philos Trans R Soc Lond B Biol Sci. 1999 Aug 29;354(1388):1447-70 PMID: 10515002
  3. The DNA sequence of human chromosome 22.
    Nature. 1999 Dec 2;402(6761):489-95 PMID: 10591208
  4. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21.
    Genome Res. 1999 Dec;9(12):1214-22 PMID: 10613844
  5. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.
    Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):206-11 PMID: 10618396
  6. MIRs as agents of mammalian gene evolution.
    Trends Genet. 2000 Feb;16(2):60-2 PMID: 10652530
  7. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.
    Genomics. 2000 Feb 1;63(3):374-83 PMID: 10704284
  8. Low-copy-number repeat sequences flank the DiGeorge/velo-cardio-facial syndrome loci at 22q11.
    Hum Mol Genet. 1993 Feb;2(2):191-6 PMID: 8499906
  9. Recognizing exons in genomic sequence using GRAIL II.
    Genet Eng (N Y). 1994;16:241-53 PMID: 7765200
  10. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
    Mamm Genome. 1994 May;5(5):253-74 PMID: 8075499
  11. The relationship between chromosome structure and function at a human telomeric region.
    Nat Genet. 1997 Mar;15(3):252-7 PMID: 9054936
  12. Prediction of complete gene structures in human genomic DNA.
    J Mol Biol. 1997 Apr 25;268(1):78-94 PMID: 9149143
  13. High-resolution recombinational map of mouse chromosome 16.
    Genomics. 1997 Jul 15;43(2):202-8 PMID: 9244437
  14. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
    Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 PMID: 9254694
  15. The DNA structures at the ends of eukaryotic chromosomes.
    Eur J Cancer. 1997 Apr;33(5):735-49 PMID: 9282112
  16. Base-calling of automated sequencer traces using phred. I. Accuracy assessment.
    Genome Res. 1998 Mar;8(3):175-85 PMID: 9521921
  17. Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10.
    Genomics. 1998 May 15;50(1):109-11 PMID: 9628829
  18. Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.
    Genomics. 1998 Jun 1;50(2):260-6 PMID: 9653653
  19. Physical and comparative mapping of distal mouse chromosome 16. 5 p5.
    Genome Res. 1998 Sep;8(9):940-50 PMID: 9750193
  20. Genome maps 10. Comparative genomics. Mammalian radiations. Wall chart.
    Science. 1999 Oct 15;286(5439):463-78 PMID: 10577209
Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.146600
Published
2000-10-00
Pages
1463-7
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC310982
Subset
IM
Grants
NICHD NIH HHS · P01 HD024605 · United States
NHGRI NIH HHS · U54 HG002153 · United States
NICHD NIH HHS · HD-24605 · United States
NHGRI NIH HHS · HG-02153 · United States
Databases
GENBANK
AC005302, AC005818, AC006507
External Links
PubMed source DOI: 10.1101/gr.146600 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2