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PMID: 11042107 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Amino-acid-dependent signal transduction.

The Biochemical journal ·Vol. 351 Pt 3 ·2000-11-01 ·Pages 545-50

van Sluijters DA, Dubbelhuis PF, Blommaart EF, Meijer AJ

Abstract

Recent research carried out in several laboratories has indicated that, in addition to their role as intermediates in many metabolic pathways, amino acids can interact with insulin-dependent signal transduction. In this short review, the current state of this rapidly expanding field is discussed.

MeSH Terms
Amino Acids/metabolism Signal Transduction/physiology
Chemicals
Amino Acids
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
van Sluijters D A
Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Dubbelhuis P F
Blommaart E F
Meijer A J
References (64)
64 references, click to expand
  1. Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-beta Ala.
    J Biol Chem. 1994 Oct 14;269(41):25348-53 PMID: 7929229
  2. Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase.
    FEBS Lett. 1999 Sep 3;457(3):489-93 PMID: 10471835
  3. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.
    Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11477-81 PMID: 7972087
  4. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes.
    J Biol Chem. 1995 Feb 3;270(5):2320-6 PMID: 7836465
  5. Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-CoA carboxylase in isolated rat hepatocytes.
    J Biol Chem. 1996 Jul 12;271(28):16668-73 PMID: 8663301
  6. Contribution of amino acids and insulin to protein anabolism during meal absorption.
    Diabetes. 1996 Sep;45(9):1245-52 PMID: 8772730
  7. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.
    EMBO J. 1996 Oct 1;15(19):5256-67 PMID: 8895571
  8. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation.
    J Biol Chem. 1999 Jan 8;274(2):1092-9 PMID: 9873056
  9. Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.
    Curr Opin Genet Dev. 1999 Feb;9(1):49-54 PMID: 10072357
  10. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein.
    Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4438-42 PMID: 10200280
  11. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.
    J Biol Chem. 1999 Apr 23;274(17):11647-52 PMID: 10206976
  12. The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs.
    FEBS Lett. 1999 Nov 5;460(3):423-6 PMID: 10556509
  13. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
    Biochem J. 1999 Dec 1;344 Pt 2:427-31 PMID: 10567225
  14. Nutrients differentially regulate multiple translation factors and their control by insulin.
    Biochem J. 1999 Dec 1;344 Pt 2:433-41 PMID: 10567226
  15. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.
    J Biol Chem. 1999 Nov 26;274(48):34493-8 PMID: 10567431
  16. Chloride affects the interaction between tyrosyl-tRNA synthetase and tRNA.
    Biochim Biophys Acta. 1999 Oct 18;1472(1-2):51-61 PMID: 10572925
  17. TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.
    Mol Cell Endocrinol. 1999 Sep 10;155(1-2):135-42 PMID: 10580846
  18. Ribosomal S6 kinase signaling and the control of translation.
    Exp Cell Res. 1999 Nov 25;253(1):100-9 PMID: 10579915
  19. Signaling by distinct classes of phosphoinositide 3-kinases.
    Exp Cell Res. 1999 Nov 25;253(1):239-54 PMID: 10579926
  20. Stimulative effect of dietary protein on the phosphorylation of p70 S6 kinase in the skeletal muscle and liver of food-deprived rats.
    Biosci Biotechnol Biochem. 1999 Oct;63(10):1803-5 PMID: 10586506
  21. Role of janus kinase-2 in insulin-mediated phosphorylation and inactivation of protein phosphatase-2A and its impact on upstream insulin signalling components.
    Biochem J. 1999 Dec 15;344 Pt 3:895-901 PMID: 10585879
  22. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.
    Nature. 1999 Dec 9;402(6762):685-9 PMID: 10604477
  23. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
    J Biol Chem. 1999 Dec 24;274(52):37400-6 PMID: 10601311
  24. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14866-70 PMID: 10611304
  25. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
    J Biol Chem. 2000 Jan 14;275(2):992-8 PMID: 10625637
  26. Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts.
    J Biol Chem. 2000 Feb 18;275(7):4803-9 PMID: 10671514
  27. The PI3K-PDK1 connection: more than just a road to PKB.
    Biochem J. 2000 Mar 15;346 Pt 3:561-76 PMID: 10698680
  28. L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport.
    Biochem J. 2000 Sep 1;350 Pt 2:361-8 PMID: 10947949
  29. Swelling of rat hepatocytes stimulates glycogen synthesis.
    J Biol Chem. 1990 Jan 15;265(2):955-9 PMID: 2295626
  30. Mechanism of activation of liver glycogen synthase by swelling.
    J Biol Chem. 1992 Mar 25;267(9):5823-8 PMID: 1348248
  31. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle.
    J Biol Chem. 1993 Feb 25;268(6):4391-8 PMID: 8382701
  32. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
    Proc Natl Acad Sci U S A. 1994 May 10;91(10):4441-5 PMID: 8183928
  33. Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte.
    Biochem Biophys Res Commun. 1994 Aug 30;203(1):200-8 PMID: 8074656
  34. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
    Eur J Biochem. 1997 Jan 15;243(1-2):240-6 PMID: 9030745
  35. Postprandial stimulation of muscle protein synthesis is independent of changes in insulin.
    Am J Physiol. 1997 May;272(5 Pt 1):E841-7 PMID: 9176184
  36. Autophagic proteolysis: control and specificity.
    Histochem J. 1997 May;29(5):365-85 PMID: 9184851
  37. Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome.
    J Biol Chem. 1997 Aug 29;272(35):21661-4 PMID: 9268289
  38. Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells.
    J Biol Chem. 1997 Sep 26;272(39):24599-603 PMID: 9305927
  39. Molecular mechanisms for the control of translation by insulin.
    Biochem J. 1997 Dec 1;328 ( Pt 2):329-41 PMID: 9371685
  40. Phosphorylation and activation of p70s6k by PDK1.
    Science. 1998 Jan 30;279(5351):707-10 PMID: 9445476
  41. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters.
    Am J Physiol. 1998 Jan;274(1 Pt 1):C206-13 PMID: 9458729
  42. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast.
    J Biol Chem. 1998 Feb 13;273(7):3963-6 PMID: 9461583
  43. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
    Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7 PMID: 9465032
  44. Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation.
    J Biol Chem. 1998 Feb 20;273(8):4485-91 PMID: 9468502
  45. Bidirectional modulation of insulin action by amino acids.
    J Clin Invest. 1998 Apr 1;101(7):1519-29 PMID: 9525995
  46. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
    J Biol Chem. 1998 May 29;273(22):13375-8 PMID: 9593664
  47. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.
    J Biol Chem. 1998 Jun 5;273(23):14484-94 PMID: 9603962
  48. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.
    J Biol Chem. 1998 Jun 26;273(26):16621-9 PMID: 9632736
  49. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway.
    Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7772-7 PMID: 9636226
  50. Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm.
    Am J Physiol. 1998 Jun;274(6 Pt 1):E1067-74 PMID: 9611157
  51. Amino acid availability regulates p70 S6 kinase and multiple translation factors.
    Biochem J. 1998 Aug 15;334 ( Pt 1):261-7 PMID: 9693128
  52. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling.
    J Biol Chem. 1998 Oct 23;273(43):28178-84 PMID: 9774438
  53. Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts.
    J Biol Chem. 1998 Nov 20;273(47):30945-53 PMID: 9812990
  54. Effect of dietary protein on translation initiation in rat skeletal muscle and liver.
    Am J Physiol. 1998 Nov;275(5 Pt 1):E814-20 PMID: 9815001
  55. Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes.
    J Biol Chem. 1998 Dec 18;273(51):34496-501 PMID: 9852118
  56. Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress.
    EMBO J. 1998 Dec 15;17(24):7294-303 PMID: 9857186
  57. Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.
    J Biol Chem. 1999 Jan 8;274(2):687-92 PMID: 9873003
  58. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells.
    J Biol Chem. 1999 Jan 8;274(2):1058-65 PMID: 9873051
  59. Structural requirement of leucine for activation of p70 S6 kinase.
    FEBS Lett. 1999 Mar 26;447(2-3):303-6 PMID: 10214966
  60. Regulation of protein kinase cascades by protein phosphatase 2A.
    Trends Biochem Sci. 1999 May;24(5):186-91 PMID: 10322434
  61. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
    Genes Dev. 1999 Jun 1;13(11):1422-37 PMID: 10364159
  62. L-Asparaginase inhibits the rapamycin-targeted signaling pathway.
    Biochem Biophys Res Commun. 1999 Jul 5;260(2):534-9 PMID: 10403802
  63. Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
    J Biol Chem. 1999 Aug 27;274(35):24731-6 PMID: 10455142
  64. Cell swelling and the control of autophagic proteolysis in hepatocytes: involvement of phosphorylation of ribosomal protein S6?
    Biochem Soc Trans. 1994 May;22(2):508-11 PMID: 7958356
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Published
2000-11-01
Pages
545-50
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1221392
Subset
IM
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