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PMID: 1100604 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

"Killer" character does not influence the transmission of mitochondrial genes in Saccharomyces cerevisiae.

Journal of bacteriology ·Vol. 124 ·No. 1 ·1975-10-00 ·Pages 290-5

Young RA, Perlman PS

Abstract

Three cytoplasmic genetic elements have been shown to be separate from mitochondrial deoxyribonucleic acid (DNA), [rho], in Saccharomyces cerevisiae: the killer character [k], omicron-DNA, and psi [psi]. Griffiths has suggested genetic interactions between [VENR] and [TETR] mutants possibly located on omicron-DNA and mitochondrial genetic markers, but possible interactions between the best characterized of the three, the killer character, and mitochondrial DNA have not been investigated. To test this we isolated cycloheximide-induced nonkiller segregants (NKS) of killer cells with suitable genetic markers and mated them in [k] x [k], [k] x [k], and (NKS) x (NKS) combinations. No differences in quantitative mitochondrial marker transmission between these groups were found in crosses illustrating the mitochondrial phenomena of bias, polarity, and suppressiveness. Our studies show that no intercellular interactions between [k] and (NKS) cells influence mitochondrial transmission genetics. Intracellular interactions between the smaller double-stranded ribonucleic acid of [k] and mitochondrial DNA also were not detected.

MeSH Terms
Chloramphenicol/pharmacology Conjugation, Genetic Crosses, Genetic Cycloheximide/pharmacology DNA Drug Resistance, Microbial Erythromycin/pharmacology Extrachromosomal Inheritance Genes Mitochondria Mutation Paromomycin/pharmacology Phenotype Saccharomyces cerevisiae/drug effects Suppression, Genetic
Chemicals
Paromomycin Erythromycin Chloramphenicol DNA Cycloheximide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Young R A
Perlman P S
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25 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.124.1.290-295.1975
Published
1975-10-00
Pages
290-5
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235895
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.124.1.290-295.1975 PMC Full Text View journal details
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