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PMID: 1098968 Published · ppublish English Journal Article

Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.

Gut ·Vol. 16 ·No. 7 ·1975-07-00 ·Pages 501-8

Thjodleifsson B, Wormsley KG

Abstract

This study has examined the inhibition produced by metiamide on the gastric secretion of acid and pepsin in 13 patients with duodenal and three with gastric ulcer. The effect of metiamide on the response to a range of doses of pentagastrin in three normal individuals was determined, as was the interaction of metiamide and atropine on prolonged basal secretion. Metiamide inhibited the secretion of acid more than pepsin and the gastric secretion of patients with gastric ulcer more than duodenal ulcer. Metiamide inhibited both the maximal secretory response attainable with pentagastrin and decreased the sensitivity to pentagastrin. Atropine augmented and prolonged the action of metiamide.

MeSH Terms
Atropine/pharmacology Dose-Response Relationship, Drug Drug Synergism Duodenal Ulcer/metabolism Gastric Juice/metabolism Humans Metiamide/pharmacology Pentagastrin/antagonists & inhibitors Pepsin A/metabolism Secretory Rate/drug effects Stomach/drug effects Stomach Ulcer/metabolism Thiourea/analogs & derivatives
Chemicals
Metiamide Atropine Pepsin A Pentagastrin Thiourea
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thjodleifsson B
Wormsley K G
References (16)
16 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.16.7.501
Published
1975-07-00
Pages
501-8
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1410974
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.16.7.501 PMC Full Text View journal details
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