Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in man.

The American journal of digestive diseases ·Vol. 19 ·No. 7 ·1974-07-00 ·Pages 609-16

Konturek SJ, Biernat J, Oleksy J

Abstract

暂无摘要

MeSH Terms

Adult Depression, Chemical Dose-Response Relationship, Drug Duodenal Ulcer/metabolism Gastric Acidity Determination Gastric Juice/metabolism Histamine/administration & dosage Humans Imidazoles/pharmacology Infusions, Parenteral Insulin/administration & dosage Intubation, Gastrointestinal Pentagastrin/administration & dosage Pepsin A/metabolism Peptones/administration & dosage Secretory Rate/drug effects Sulfides/pharmacology Thiourea/pharmacology

Chemicals

Imidazoles Insulin Peptones Sulfides Histamine Pepsin A Pentagastrin Thiourea

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Konturek S J

Biernat J

Oleksy J

References (11)

11 references, click to expand

Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors.
Gastroenterology. 1974 Apr;66(4):517-21 PMID: 4150710
POTENTIATION OF SHAM FEEDING RESPONSE IN PAVLOV POUCH DOGS BY SUBTHRESHOLD AMOUNTS OF GASTRIN WITH AND WITHOUT ACIDIFICATION OF DENERVATED ANTRUM.
Acta Physiol Scand. 1964 Jul;61:244-54 PMID: 14196581
THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.
J Gen Physiol. 1938 Sep 20;22(1):79-89 PMID: 19873094
Secretion of gastrointestinal hormones.
Annu Rev Physiol. 1973;35:431-52 PMID: 4581769
Definition and antagonism of histamine H 2 -receptors.
Nature. 1972 Apr 21;236(5347):385-90 PMID: 4401751
Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer.
J Clin Invest. 1973 Mar;52(3):645-57 PMID: 4685087
Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats.
Am J Dig Dis. 1974 Jun;19(6):557-64 PMID: 4597820
Histamine and gastric secretion: a later look, 1955-1965.
Fed Proc. 1965 Nov-Dec;24(6):1311-21 PMID: 5322404
Control of gastric secretion: no room for histamine?
Gastroenterology. 1971 Jul;61(1):106-18 PMID: 4932551
Inhibition of gastric secretion in man by metiamide: a new, orally active histamine H 2 -receptor antagonist.
Gut. 1973 May;14(5):424 PMID: 4146085
The control of pepsinogen secretion.
Ann N Y Acad Sci. 1967 Jan 26;140(2):709-23 PMID: 4961720

Article Info

Journal

The American journal of digestive diseases

Abbr.

Am J Dig Dis

ISSN

0002-9211

DOI

10.1007/BF01073015

Published

1974-07-00

Pages

609-16

Language

English

Region

United States

NLM ID

0404011

Subset

External Links

PubMed source DOI: 10.1007/BF01073015

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Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in man.

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