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PMID: 10935026 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

A role for fibroblast growth factor signaling in the lobuloalveolar development of the mammary gland.

Journal of mammary gland biology and neoplasia ·Vol. 2 ·No. 4 ·1997-10-00 ·Pages 385-92

Jackson D, Bresnick J, Dickson C

Abstract

The inappropriate expression of growth factors, or activating mutations of their receptors, have been implicated as causative factors in mouse and human mammary cancer. For example, it has been known for some time that three members of the fibroblast growth factor (FGF) family behave like oncogenes in virally induced mammary cancer of mice. In normal circumstances, signaling via FGF receptors is known to mediate growth, differentiation, and patterning, during embryogenesis and fetal development. A powerful approach to dissecting the roles for these signaling pathways is to determine the developmental consequences of abrogating their function in transgenic mice. In this review, we describe the use of dominant negative FGF receptors to evaluate the contribution of specific FGF signals in normal mammary gland development. These studies have revealed that normal lobuloalveolar development requires FGF signaling to the mammary epithelium, a function that is presumably usurped by MMTV in mouse mammary tumorigenesis.

MeSH Terms
Animals Female Fibroblast Growth Factors/physiology Humans Mammary Glands, Animal/embryology,physiology Mice Mice, Transgenic Mutation Receptors, Fibroblast Growth Factor/physiology Signal Transduction
Chemicals
Receptors, Fibroblast Growth Factor Fibroblast Growth Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jackson D
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, London, United Kingdom.
Bresnick J
Dickson C
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1026351414004
Published
1997-10-00
Pages
385-92
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1026351414004 View journal details
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