Molecular pathogenesis of systemic lupus erythematosus.

Archives of virology ·Vol. 47 ·No. 2 ·1975-00-00 ·Pages 109-21

Alekberova ZS, Parfanovich MI, Nasonova VA, Zhdanov VM

Abstract

The study of patients with systemic lupus erythematosus revealed the close association of the disease with measles--or a related virus. High titres of antibodies to measles virus were found in patients that correlated with the course of the disease. Immunofluorescence tests revealed measles virus or a related antigen in lupus-affected tissues. Inclusion bodies consisting of paramyxovirus-like ribonucleoprotein structures were regularly detected in both affected tissues and leukocytes. Molecular hybridization of measles virus RNA with DNA from the affected tissues showed that DNA transcripts of measles or a closely related virus are integrated in the cellular nuclear DNA. Possible pathogenetic mechanisms of the disease are discussed.

MeSH Terms

Adolescent Adult Antibodies, Viral/analysis Capillaries/ultrastructure Cell Nucleus/ultrastructure Fluorescent Antibody Technique Humans Inclusion Bodies, Viral/ultrastructure Kidney/pathology Knee Joint Lupus Erythematosus, Systemic/etiology,immunology,pathology Measles/complications Measles virus/immunology Middle Aged Nucleic Acid Hybridization Skin/pathology Synovial Membrane/ultrastructure

Chemicals

Antibodies, Viral

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Alekberova Z S

Parfanovich M I

Nasonova V A

Zhdanov V M

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28 references, click to expand

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Article Info

Journal

Archives of virology

Abbr.

Arch Virol

ISSN

0304-8608

DOI

10.1007/BF01320551

Published

1975-00-00

Pages

109-21

Language

English

Region

Austria

NLM ID

7506870

PMCID

PMC7086617

Subset

External Links

PubMed source DOI: 10.1007/BF01320551 PMC Full Text View journal details

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