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PMID: 10887517 Published · ppublish English Journal Article Review

Prolactin as a mitogen in mammary cells.

Journal of mammary gland biology and neoplasia ·Vol. 2 ·No. 1 ·1997-01-00 ·Pages 29-39

Das R, Vonderhaar BK

Abstract

Prolactin (PRL) acts as both a mitogen and a differentiating agent in the breast. The decision to respond to PRL as a mitogen by breast cells depends on the hormonal milieu in which the epithelial cell resides. In addition, PRL's action on the breast is regulated (1) at the level of the hormone itself; (2) at the receptor level; (3) at the level of selection of signaling pathway; and, (4) by combinations of these aspects. The development of cell lines containing only one class of the PRL receptors and showing qualitative differences in response and signaling pathways will help in understanding the pleiotropic nature of PRL action.

MeSH Terms
Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Animals Breast/cytology Breast Neoplasms/pathology Humans MAP Kinase Signaling System Mammary Glands, Animal/cytology Mitogens/physiology Prolactin/physiology Protein Kinase C/physiology Protein Processing, Post-Translational Proteins/physiology Receptors, Prolactin/physiology Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 1
Chemicals
Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Mitogens Proteins Receptors, Prolactin SHC1 protein, human Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 1 Prolactin Protein Kinase C
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Das R
Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Vonderhaar B K
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1026369412612
Published
1997-01-00
Pages
29-39
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1026369412612 View journal details
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