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PMID: 10887489 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cyclins and breast cancer.

Journal of mammary gland biology and neoplasia ·Vol. 1 ·No. 2 ·1996-04-00 ·Pages 153-62

Musgrove EA, Hui R, Sweeney KJ, Watts CK, Sutherland RL

Abstract

Recent advances in the understanding of cell cycle control by cyclins and cyclin-dependent kinases provide a basis for delineating the molecular mechanisms of proliferation control by steroids and the development and progression of hormone-dependent cancers. Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation. The cyclin D1 gene is amplified in approximately 15%, and its product overexpressed in 40-50%, of primary breast carcinomas. The strong evidence that cyclin D1 plays a major role in cell cycle control in breast epithelial cells suggests that its deregulated expression may have effects on disease progression and phenotype including sensitivity to endocrine therapies.

MeSH Terms
Breast Neoplasms/genetics,metabolism,pathology Cell Cycle Cell Division Cyclins/genetics,metabolism Female Gene Expression Regulation, Neoplastic Humans
Chemicals
Cyclins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Musgrove E A
Cancer Biology Division, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, NSW, Australia.
Hui R
Sweeney K J
Watts C K
Sutherland R L
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1007/BF02013639
Published
1996-04-00
Pages
153-62
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02013639 View journal details
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