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PMID: 10872327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Latent and lytic cycle promoters of Epstein-Barr virus.

The EMBO journal ·Vol. 2 ·No. 8 ·1983-00-00 ·Pages 1331-8

Farrell PJ, Bankier A, Séguin C, Deininger P, Barrell BG

Abstract

Four RNA polymerase II promoters have been mapped in the DNA sequence of the EcoRI-H and -Dhet fragments of B95-8 Epstein-Barr virus. RNAs transcribed from three of these promoters are dramatically induced by treatment of B95-8 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA). The other promoter is active with or without TPA treatment of the cells and is thus active in the latent virus cycle. Deletion mapping suggests that DNA sequence homologies between some of the promoters lie in the same region as essential upstream promoter elements.

MeSH Terms

Base Sequence HeLa Cells Herpesvirus 4, Human/enzymology,genetics Humans Molecular Sequence Data Promoter Regions, Genetic RNA Polymerase II/genetics Sequence Homology, Nucleic Acid Transcription, Genetic Virus Latency

Chemicals

RNA Polymerase II

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Farrell P J

Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, UK.

Bankier A

Séguin C

Deininger P

Barrell B G

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15 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1983-00-00

Pages

1331-8

Language

English

Region

England

NLM ID

8208664

PMCID

PMC555279

Subset

External Links

PubMed source PMC Full Text View journal details

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