Lymphocytotoxins in acute and chronic hepatitis. Characterization and relationship to changes in circulating T lymphocytes.

Clinical and experimental immunology ·Vol. 26 ·No. 1 ·1976-10-00 ·Pages 21-7

Dehoratius RJ, Henderson C, Strickland RG

Abstract

Serum lymphocytotoxicity (LCT) was detected in 49% of fifty-one patients with acute viral hepatitis and 72% of twenty-nine patients with chronic hepatitis. LCT was not detected in ten chronic carriers of hepatitis B surface antigen. Characterization of LCT revealed it to be active at physiologic temperatures and to be reactive against both T and B lymphocytes. The occurrence of LCT was transient in acute hepatitis and intermittent in chronic hepatitis. There was a significant inverse relationship between the percentage change in LCT over time and peripheral blood T-cell proportions amongst the patients studied. These findings indicate the importance of liver damage in the appearance of LCT and suggest that LCT may contribute to depressed lymphocyte function in liver disease.

MeSH Terms

Absorption Adolescent Adult B-Lymphocytes Cytotoxicity Tests, Immunologic Hepatitis/immunology Hepatitis B Surface Antigens Hepatitis, Viral, Human/immunology Humans Leukocyte Count Lymphocytes/immunology Middle Aged T-Lymphocytes/immunology Temperature

Chemicals

Hepatitis B Surface Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dehoratius R J

Henderson C

Strickland R G

References (27)

27 references, click to expand

Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis.
Lancet. 1974 Dec 28;2(7896):1543-5 PMID: 4140983
A classification of chronic hepatitis.
Lancet. 1968 Sep 14;2(7568):626-8 PMID: 4175170
Lymphocyte stimulation in hepatitis B infections.
N Engl J Med. 1975 Aug 14;293(7):318-22 PMID: 1152922
Localization of T and B cells and alpha fetoprotein in hepatic biopsies from patients with liver disease.
J Clin Invest. 1975 Nov;56(5):1198-1209 PMID: 52655
Lymphocyte function in normal people with persistent Australia antigen.
J Lab Clin Med. 1973 Jul;82(1):79-85 PMID: 4197992
Separation of cells according to surface antigens by the use of antibody-coated columns. Fractionation of cells carrying immunoglobulins and blood group antigen.
Scand J Immunol. 1972;1(1):75-87 PMID: 4627539
Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus.
Arthritis Rheum. 1973 May-Jun;16(3):369-75 PMID: 4575171
Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus.
J Clin Invest. 1973 Dec;52(12):3046-56 PMID: 4584345
Studies of T- and B-lymphocytes in patients with connective tissue diseases.
J Clin Invest. 1973 Feb;52(2):283-95 PMID: 4567306
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS.
Nature. 1964 Dec 5;204:998-1000 PMID: 14248725
Antibody to hepatitis-B-virus core in man.
Lancet. 1973 Oct 20;2(7834):869-73 PMID: 4126916
Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes.
Scand J Immunol. 1972;1(3):269-80 PMID: 4541574
Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.
J Exp Med. 1972 Aug 1;136(2):207-15 PMID: 4114496
The human rosette-forming cell as a marker of a population of thymus-derived cells.
J Clin Invest. 1972 Oct;51(10):2537-43 PMID: 4115705
Nature of cold-reactive antibodies to lymphocyte surface determinants in systemic lupus erythematosus.
Arthritis Rheum. 1975 Jan-Feb;18(1):1-8 PMID: 46753
T and B lymphocytes in acute and chronic hepatitis.
Clin Immunol Immunopathol. 1974 Apr;2(3):353-60 PMID: 4596968
Antibodies to a specific surface antigen of T cells in human sera inhibiting mixed leukocyte culture reactions.
J Exp Med. 1973 Oct 1;138(4):1021-6 PMID: 4542734
Purification of human T and B lymphocytes.
J Immunol. 1974 Jan;112(1):420-3 PMID: 4544194
Lymphocyte E rosette inhibitory factor: a regulatory serum lipoprotein.
J Exp Med. 1975 Nov 1;142(5):1092-1107 PMID: 172585
Rapid detection of Australia antigen by counterimmunoelectrophoresis.
J Immunol. 1970 Apr;104(4):1031-4 PMID: 4986160
Immunoglobulin spots on the surface of rabbit lymphocytes.
J Exp Med. 1970 Nov;132(5):1001-18 PMID: 4919141
Thymus-derived lymphocytes in type B acute viral hepatitis and healthy carriers of hepatitis B surface antigen (HBsAg).
Am J Dig Dis. 1975 Jun;20(6):518-22 PMID: 1093393
Cell-mediated immunity in acute and chronic hepatitis.
J Clin Invest. 1975 May;55(5):921-9 PMID: 1079030
Lymphocyte subpopulations in chronic active hepatitis: increase in lymphocytes forming stable E-rosettes.
Clin Immunol Immunopathol. 1975 Nov;4(4):538-44 PMID: 1081936
Serum lymphocytotoxins in inflammatory bowel disease. Studies of frequency and specificity for lymphocyte subpopulations.
Clin Exp Immunol. 1975 Sep;21(3):384-93 PMID: 1081934
Association of cold-reactive antilymphocyte antibodies with lymphopenia in systemic lupus erythematosus.
Arthritis Rheum. 1975 Nov-Dec;18(6):587-94 PMID: 1081876
Proceedings: Lymphocyte populations in chronic liver disease.
Gut. 1975 Oct;16(10):828 PMID: 1205293

Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1976-10-00

Pages

21-7

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1540808

Subset

External Links

PubMed source PMC Full Text View journal details

Analysis Services

Lymphocytotoxins in acute and chronic hepatitis. Characterization and relationship to changes in circulating T lymphocytes.

Contact

WeChat Official Account