Expression of Ia antigens on hapten-specific B cells. I. Delineation of B-cell subpopulations.
The nonimmune adult spleen contains at least two B-cell subpopulations. The majority of primary B cells express cell surface Ia determinants and have the capacity to give rise to IgG antibody-producing clones after T-cell dependent antigenic stimulation. There is also a small subpopulation of primary B cells which are, by definition, Ia negative, since their activity is not eliminated by negative selection with anti-Ia serum and complement. The Ia-negative B cells give rise to clones that produce only IgM antibody. These B-cell subsets may form a continuum in B-cell maturation, or they may exist as discrete B-cell lineages. Since the cellular expression of Ia antigens appears to correlate with the ability of the B cell to generate IgG-producing clones, it is speculated that Ia molecules may have a role in the IgM to IgG B-cell switch mechanism.
26 references, click to expand
-
Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.J Exp Med. 1974 Dec 1;140(6):1660-75 PMID: 4139235
-
The mechanism of antigenic stimulation of primary and secondary clonal precursor cells.J Exp Med. 1972 Aug 1;136(2):241-60 PMID: 4114497
-
Activation of T and B lymphocytes in vitro. III. Presence of Ia determinants on allogeneic effect factor.J Exp Med. 1974 Dec 1;140(6):1717-22 PMID: 4139236
-
I-region genes are expressed on T and B lymphocytes. Studies of the mixed lymphocyte reaction (MLR).J Exp Med. 1974 Nov 1;140(5):1317-23 PMID: 4153771
-
B-cell alloantigens determined by the H-2 linked Ir region are associated with mixed lymphocyte culture stimulation.Science. 1974 Feb 22;183(4126):757-9 PMID: 4150717
-
The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.Adv Immunol. 1975;20:125-95 PMID: 47219
-
Development and application of a rapid cell sorter.Clin Chem. 1973 Aug;19(8):813-6 PMID: 4200173
-
Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.J Exp Med. 1974 Dec 1;140(6):1579-87 PMID: 4610078
-
Genetic and functional analysis of the Ia antigens: their possible role in regulating the immune response.Transplant Rev. 1976;30:197-235 PMID: 59973
-
Complementary genes controlling immune response to theta-AKR antigen in mice.J Immunol. 1973 May;110(5):1238-44 PMID: 4572633
-
The B cell specificity repertoire: its relationship to definable subpopulations.Transplant Rev. 1975;24:41-83 PMID: 49962
-
The possible role of i region determined cell surface molecules in the regulation of immune responses.Transplant Rev. 1975;23:159-75 PMID: 49099
-
Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.J Exp Med. 1975 Oct 1;142(4):989-97 PMID: 51901
-
Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene.J Exp Med. 1973 Sep 1;138(3):734-9 PMID: 4542255
-
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.J Exp Med. 1974 Nov 1;140(5):1273-84 PMID: 4547437
-
Genetic control of the immune response. Mapping of the Ir-1 locus.J Exp Med. 1972 Jun 1;135(6):1259-78 PMID: 4554451
-
Monoclonal production of both IgM and IgG1 antihapten antibody.J Exp Med. 1973 Jul 1;138(1):300-5 PMID: 4736831
-
General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice.Clin Exp Immunol. 1969 Apr;4(4):473-87 PMID: 5305881
-
The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses.J Exp Med. 1975 Nov 1;142(5):1165-79 PMID: 811749
-
Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter.J Immunol. 1975 Aug;115(2):584-9 PMID: 1097521
-
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.J Exp Med. 1975 Jan 1;141(1):263-8 PMID: 1090698
-
Properties of primed suppressor T cells and their products.Transplant Rev. 1975;26:106-29 PMID: 1101468
-
Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.Proc Natl Acad Sci U S A. 1975 May;72(5):1707-11 PMID: 1080568
-
Cell interactions between histoincompatible T and B lymphocytes. VIII. In vivo cooperative responses between lymphocytes are controlled by genes in the K-end of the H-2 complex.J Immunol. 1975 Jun;114(6):1717-9 PMID: 1079217
-
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.Transplant Rev. 1975;22:175-95 PMID: 1078737
-
Serologic and biochemical studies of the Ia system of the mouse H-2 gene complex. Further evidence for I-C subregion.J Immunol. 1975 Apr;114(4):1205-9 PMID: 1117139
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
