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PMID: 10840056 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Opiates inhibit neurogenesis in the adult rat hippocampus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 13 ·2000-06-20 ·Pages 7579-84

Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ

Abstract

Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal function, we examined opiate regulation of neurogenesis in this brain region. Chronic administration of morphine decreased neurogenesis by 42% in the adult rat hippocampal granule cell layer. A similar effect was seen in rats after chronic self-administration of heroin. Opiate regulation of neurogenesis was not mediated by changes in circulating levels of glucocorticoids, because similar effects were seen in rats that received adrenalectomy and corticosterone replacement. These findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.

MeSH Terms
Analgesics, Opioid/pharmacology Animals Cell Differentiation/drug effects Heroin/pharmacology Hippocampus/cytology,drug effects Male Morphine/pharmacology Narcotics/pharmacology Neurons/cytology,drug effects Rats Rats, Sprague-Dawley
Chemicals
Analgesics, Opioid Narcotics Heroin Morphine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Eisch A J
Laboratory of Molecular Psychiatry and Yale Center for Genes and Behavior, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA.
Barrot M
Schad C A
Self D W
Nestler E J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.120552597
Published
2000-06-20
Pages
7579-84
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC16588
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.120552597 PMC Full Text View journal details
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