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PMID: 10835339 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Receptor recognition by gp130 cytokines.

The EMBO journal ·Vol. 19 ·No. 11 ·2000-06-01 ·Pages 2399-411

Bravo J, Heath JK

Abstract

Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three-dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.

MeSH Terms
Antigens, CD/metabolism Cytokine Receptor gp130 Cytokines/chemistry,metabolism Dimerization Drug Design Epitopes/chemistry Growth Inhibitors/chemistry Human Growth Hormone/chemistry,metabolism Humans Interleukin-6/chemistry Leukemia Inhibitory Factor Ligands Lymphokines/chemistry Membrane Glycoproteins/metabolism Models, Molecular Multigene Family Mutagenesis, Site-Directed Protein Binding Protein Conformation Protein Structure, Tertiary Receptors, Cytokine/metabolism Receptors, Somatotropin/chemistry,metabolism Signal Transduction/physiology Structure-Activity Relationship
Chemicals
Antigens, CD Cytokines Epitopes Growth Inhibitors IL6ST protein, human Interleukin-6 LIF protein, human Leukemia Inhibitory Factor Ligands Lymphokines Membrane Glycoproteins Receptors, Cytokine Receptors, Somatotropin Human Growth Hormone Cytokine Receptor gp130
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bravo J
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Heath J K
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/19.11.2399
Published
2000-06-01
Pages
2399-411
Language
English
Region
England
NLM ID
8208664
PMCID
PMC212748
Subset
IM
External Links
PubMed source DOI: 10.1093/emboj/19.11.2399 PMC Full Text View journal details
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