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PMID: 1080129 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Independent appearance of anti-thymocyte and anti-RNA antibodies in NZB/NZW F1 mice.

Immunology ·Vol. 28 ·No. 4 ·1975-04-00 ·Pages 621-8

Goldblum R, Pillarisetty R, Talal N

Abstract

NZB and NZB/NZW (B/W) mice were studied for natural thymocytoxic autoantibody(NTA) and antibody to reovirus RNA by cytotoxicity and radioimmunoassay respectively.NZB mice developed NTA by 2-3 months of age. RNA antibodies appeared later if atall. NTA and anti-RNA were present in B/W mice starting at 4-5 months and increased in frequency with age. Either activity could appear first and could be present without the other. Thus, all four possible patterns of autoantibody occurrence were found. NTA and anti-RNA in 12-month B/W sera were separable by sucrose density gradient ultracentrifugation; NTA is a 19S IgM antibody whereas anti-RNA is 7S.

MeSH Terms
Animals Antibody Formation Antilymphocyte Serum Autoantibodies/analysis Centrifugation, Density Gradient Cytotoxicity Tests, Immunologic Immunoglobulin M/analysis Mice Mice, Inbred C57BL Mice, Inbred NZB/immunology Mice, Inbred Strains RNA, Viral/immunology Radioimmunoassay Reoviridae/immunology T-Lymphocytes/immunology
Chemicals
Antilymphocyte Serum Autoantibodies Immunoglobulin M RNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Goldblum R
Pillarisetty R
Talal N
References (32)
32 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1975-04-00
Pages
621-8
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445848
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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